Biology:LAGLIDADG RNA motifs
From HandWiki
| LAGLIDADG-2 | |
|---|---|
 Consensus secondary structure and sequence conservation of LAGLIDADG-2 RNA | |
| Identifiers | |
| Symbol | LAGLIDADG-2 |
| Rfam | RF03094 |
| Other data | |
| RNA type | Gene; sRNA |
| SO | 0001263 |
| PDB structures | PDBe |
LAGLIDADG RNA motifs are conserved RNA structures that were discovered by bioinformatics.[1] These RNA motifs are associated with genes that encode endonucleases of the LAGLIDADG variety. Although group I introns are often present in self-replicating elements that use LAGLIDADG endonucleases, the known LAGLIDADG RNA motifs appear too small and structurally simple to function as a self-splicing intron.
A LAGLIDADG-1 motif RNA is predicted in the fungus Trametes cingulata as well as many metagenomic sequences, which presumably are derived from other fungi. LAGLIDADG-2 motif RNAs are found in Halobacteria. It is ambiguous whether LAGLIDADG-1 RNAs function as cis-regulatory elements or whether they operate in trans.
References
- ↑ "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. October 2017. doi:10.1093/nar/gkx699. PMID 28977401.
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