Biology:LGALS3BP

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A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Galectin-3-binding protein is a protein that in humans is encoded by the LGALS3BP gene.[1][2][3][4]

Function

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell–cell and cell–matrix interactions. Using fluorescence in–situ hybridization, the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds to galectin 1.[4]

Clinical significance

LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity.[4]

Interactions

LGALS3BP has been shown to interact with LGALS3.[3][5][6]

References

  1. "The gene (LGALS3BP) encoding the serum protein 90K, associated with cancer and infection by the human immunodeficiency virus, maps at 17q25". Cytogenet Cell Genet 69 (3–4): 223–5. May 1995. doi:10.1159/000133969. PMID 7698018. 
  2. "The secreted tumor-associated antigen 90K is a potent immune stimulator". J Biol Chem 269 (28): 18401–7. Aug 1994. doi:10.1016/S0021-9258(17)32322-0. PMID 8034587. 
  3. 3.0 3.1 "Cloning and characterization of a human Mac-2-binding protein, a new member of the superfamily defined by the macrophage scavenger receptor cysteine-rich domain". J. Biol. Chem. 268 (19): 14245–9. July 1993. doi:10.1016/S0021-9258(19)85233-X. PMID 8390986. 
  4. 4.0 4.1 4.2 "Entrez Gene: LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3959. 
  5. "Mac-2-binding glycoproteins. Putative ligands for a cytosolic beta-galactoside lectin". J. Biol. Chem. 266 (28): 18731–6. October 1991. doi:10.1016/S0021-9258(18)55124-3. PMID 1917996. 
  6. "Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation". Int. J. Cancer 91 (2): 167–72. January 2001. doi:10.1002/1097-0215(200002)9999:9999<::AID-IJC1022>3.3.CO;2-Q. PMID 11146440. 

Further reading