Biology:MAGEA2
 Generic protein structure example |
Melanoma-associated antigen 2 is a protein that in humans is encoded by the MAGEA2 gene.[1][2][3]
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.[3]
References
- ↑ "A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma". Science 254 (5038): 1643–7. Jan 1992. doi:10.1126/science.1840703. PMID 1840703.
- ↑ "The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28". Genomics 29 (3): 725–31. Mar 1996. doi:10.1006/geno.1995.9945. PMID 8575766.
- ↑ 3.0 3.1 "Entrez Gene: MAGEA2 melanoma antigen family A, 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4101.
Further reading
- "Expression of MAGE genes in primary and metastatic cutaneous melanoma.". Int. J. Cancer 63 (3): 375–80. 1995. doi:10.1002/ijc.2910630313. PMID 7591235.
- "Structure, chromosomal localization, and expression of 12 genes of the MAGE family.". Immunogenetics 40 (5): 360–9. 1994. doi:10.1007/BF01246677. PMID 7927540.
- "Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes.". J. Exp. Med. 179 (3): 921–30. 1994. doi:10.1084/jem.179.3.921. PMID 8113684.
- "Sequence and expression pattern of the human MAGE2 gene.". Immunogenetics 39 (2): 121–9. 1994. doi:10.1007/bf00188615. PMID 8276455.
- "Differential expression of MAGE-1, -2, and -3 messenger RNA in transformed and normal human cell lines.". Cancer Res. 53 (1): 5–8. 1993. PMID 8416750.
- "Comparative genome sequence analysis of the Bpa/Str region in mouse and Man.". Genome Res. 10 (6): 758–75. 2000. doi:10.1101/gr.10.6.758. PMID 10854409.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity.". J. Biol. Chem. 278 (12): 10668–74. 2003. doi:10.1074/jbc.M206104200. PMID 12525503.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents.". Proc. Natl. Acad. Sci. U.S.A. 103 (30): 11160–5. 2006. doi:10.1073/pnas.0510834103. PMID 16847267. Bibcode: 2006PNAS..10311160M.
- "Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters.". Mol. Cancer Res. 5 (7): 749–59. 2007. doi:10.1158/1541-7786.MCR-06-0364. PMID 17634428.
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