Biology:MHC class I polypeptide–related sequence B

Generic protein structure example

MHC class I polypeptide-related sequence B (MICB) is a protein that is encoded by the MICB gene located within MHC locus. MICB is related to MHC class I and has similar domain structure, which is made up of external α1α2α3 domain, transmembrane segment and C-terminal cytoplasmic tail. MICB is a stress-induced ligand for NKG2D receptor. The heat shock stress pathway is involved in the regulation of MICB expression as transcription of MICB is regulated by promoter heat shock element.

See also

• MICA

Further reading

• "Functions of nonclassical MHC and non-MHC-encoded class I molecules". Current Opinion in Immunology 11 (1): 100–8. Feb 1999. doi:10.1016/S0952-7915(99)80018-1. PMID 10047540. 
• "Structure and function of major histocompatibility complex (MHC) class I specific receptors expressed on human natural killer (NK) cells". Molecular Immunology 38 (9): 637–60. Feb 2002. doi:10.1016/S0161-5890(01)00107-9. PMID 11858820. https://zenodo.org/record/1259843. 
• "A new polymorphic and multicopy MHC gene family related to nonmammalian class I". Immunogenetics 40 (5): 339–51. 1994. doi:10.1007/BF01246675. PMID 7927538. 
• "Nucleotide sequence of a human MHC class I MICB cDNA". Immunogenetics 43 (4): 230–3. 1996. doi:10.1007/s002510050051. PMID 8575823. 
• "Genes in a 220-kb region spanning the TNF cluster in human MHC". Genomics 31 (2): 215–22. Jan 1996. doi:10.1006/geno.1996.0034. PMID 8824804. 
• "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. Sep 1996. doi:10.1101/gr.6.9.791. PMID 8889548. 
• "Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium". Proceedings of the National Academy of Sciences of the United States of America 93 (22): 12445–50. Oct 1996. doi:10.1073/pnas.93.22.12445. PMID 8901601. 
• "Genomic structure of the human MHC class I MICB gene". Immunogenetics 45 (2): 161–2. 1997. doi:10.1007/s002510050184. PMID 8952966. 
• "Allelic and interlocus comparison of the PERB11 multigene family in the MHC". Immunogenetics 45 (3): 209–16. 1997. doi:10.1007/s002510050191. PMID 8995188. 
• "Allelic repertoire of the human MICB gene". Immunogenetics 46 (5): 434–6. 1997. doi:10.1007/s002510050299. PMID 9271635. 
• "Allelic variants of the human MHC class I chain-related B gene (MICB)". Immunogenetics 46 (6): 499–508. 1997. doi:10.1007/s002510050311. PMID 9321430. 
• "Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells". Science 279 (5357): 1737–40. Mar 1998. doi:10.1126/science.279.5357.1737. PMID 9497295. 
• "Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles". Tissue Antigens 51 (6): 649–52. Jun 1998. doi:10.1111/j.1399-0039.1998.tb03008.x. PMID 9694358. 
• "Diversification, expression, and gamma delta T cell recognition of evolutionarily distant members of the MIC family of major histocompatibility complex class I-related molecules". Proceedings of the National Academy of Sciences of the United States of America 95 (21): 12510–5. Oct 1998. doi:10.1073/pnas.95.21.12510. PMID 9770516. 
• "Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB". Proceedings of the National Academy of Sciences of the United States of America 96 (12): 6879–84. Jun 1999. doi:10.1073/pnas.96.12.6879. PMID 10359807. 
• "PERB11 (MIC): a polymorphic MHC gene is expressed in skin and single nucleotide polymorphisms are associated with psoriasis". Clinical and Experimental Immunology 119 (3): 553–8. Mar 2000. doi:10.1046/j.1365-2249.2000.01140.x. PMID 10691930. 
• "Three novel MICB alleles". Tissue Antigens 55 (2): 166–70. Feb 2000. doi:10.1034/j.1399-0039.2000.550210.x. PMID 10746790. 
• "Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice". Immunity 12 (6): 721–7. Jun 2000. doi:10.1016/S1074-7613(00)80222-8. PMID 10894171.