Biology:MIR517C

Short description: Protein

Generic protein structure example

MicroRNA 517c is a protein that in humans is encoded by the MIR517C gene.

Function

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009].

Further reading

• "Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors". Cancer Cell 16 (6): 533–46. December 2009. doi:10.1016/j.ccr.2009.10.025. PMID 19962671. 
• "Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2". Cancer Lett. 329 (2): 164–73. February 2013. doi:10.1016/j.canlet.2012.10.027. PMID 23142219. 
• "Placental expression of miR-517a/b and miR-517c contributes to trophoblast dysfunction and preeclampsia". PLOS ONE 10 (3): e0122707. 2015. doi:10.1371/journal.pone.0122707. PMID 25799546. Bibcode: 2015PLoSO..1022707A. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.