Biology:MPDZ

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Multiple PDZ domain protein is a protein that in humans is encoded by the MPDZ gene.

Interactions

MPDZ has been shown to interact with:

• 5-HT2C receptor,
• CD117, and
• PLEKHA1.

Further reading

• "Cloning and characterization of MUPP1, a novel PDZ domain protein". FEBS Lett. 424 (1–2): 63–8. 1998. doi:10.1016/S0014-5793(98)00141-0. PMID 9537516. 
• "The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2". J. Cell. Biochem. 79 (2): 213–24. 2000. doi:10.1002/1097-4644(20001101)79:2<213::AID-JCB50>3.0.CO;2-G. PMID 10967549. 
• "Multi-PDZ Domain Protein MUPP1 Is a Cellular Target for both Adenovirus E4-ORF1 and High-Risk Papillomavirus Type 18 E6 Oncoproteins". J. Virol. 74 (20): 9680–93. 2000. doi:10.1128/JVI.74.20.9680-9693.2000. PMID 11000240. 
• "The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity". FEBS Lett. 482 (1–2): 54–8. 2000. doi:10.1016/S0014-5793(00)02036-6. PMID 11018522. 
• "Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1". J. Biol. Chem. 276 (16): 12974–82. 2001. doi:10.1074/jbc.M008089200. PMID 11150294. 
• "TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm". Genes Dev. 15 (10): 1229–41. 2001. doi:10.1101/gad.888601. PMID 11358867. 
• "Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule". J. Biol. Chem. 277 (1): 455–61. 2002. doi:10.1074/jbc.M109005200. PMID 11689568. 
• "Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo". Biochem. J. 361 (Pt 3): 525–36. 2002. doi:10.1042/0264-6021:3610525. PMID 11802782. 
• "Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells". J. Cell Biol. 159 (2): 361–72. 2002. doi:10.1083/jcb.200207050. PMID 12403818. 
• "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors". Brain Res. Mol. Brain Res. 117 (1): 47–57. 2003. doi:10.1016/S0169-328X(03)00283-3. PMID 14499480. 
• "SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation". Neuron 43 (4): 563–74. 2004. doi:10.1016/j.neuron.2004.08.003. PMID 15312654. 
• "Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure". J. Cell Sci. 117 (Pt 18): 4169–77. 2005. doi:10.1242/jcs.01301. PMID 15316081. 
• "The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction". J. Biol. Chem. 279 (46): 48079–84. 2005. doi:10.1074/jbc.M409061200. PMID 15364909. 
• "Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux". J. Biol. Chem. 280 (47): 39653–64. 2006. doi:10.1074/jbc.M510187200. PMID 16192269. 
• "The multi PDZ domain protein MUPP1 as a putative scaffolding protein for organizing signaling complexes in the acrosome of mammalian spermatozoa". J. Androl. 27 (3): 390–404. 2006. doi:10.2164/jandrol.05166. PMID 16452527. 
• "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biology 8 (8): R154. 2007. doi:10.1186/gb-2007-8-8-r154. PMID 17672918.