Biology:MXRA5
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Matrix-remodelling associated 5 is a protein in humans that is encoded by the MXRA5 gene.[1]
Function
This gene encodes one of the matrix-remodelling associated proteins. This protein contains 7 leucine-rich repeats and 12 immunoglobulin-like C2-type domains related to perlecan. This gene has a pseudogene on chromosome Y.[1]
Clinical relevance
Mutations in this gene have been seen frequently mutated in cases of non-small cell lung carcinoma.[2]
References
- ↑ 1.0 1.1 "Entrez Gene: Matrix-remodelling associated 5". https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=25878.
- ↑ "Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients". Carcinogenesis 33 (9): 1797–805. Sep 2012. doi:10.1093/carcin/bgs210. PMID 22696596.
Further reading
- "Cloning of differentially expressed genes in skin fibroblasts from centenarians". Biogerontology 5 (6): 401–9. 2004. doi:10.1007/s10522-004-3188-1. PMID 15609104.
- "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics 84 (1): 205–10. Jul 2004. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
- "Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon". Oncogene 21 (31): 4855–62. Jul 2002. doi:10.1038/sj.onc.1205613. PMID 12101425.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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