Biology:MYLIP
 Generic protein structure example |
Myosin regulatory light chain interacting protein, also known as MYLIP, is a protein that in humans is encoded by the MYLIP gene.[1]
MYLIP is also known as IDOL "Inducible Degrader of the LDL receptor" based on its involvement in cholesterol regulation.[2][3] The expression of IDOL is induced by the sterol-activated liver X receptor.
Increased Degradation of LDL Receptor Protein (IDOL) is a ubiquitin ligase that ubiquinates LDL receptors in endosomes and directs the receptors to the lysosomal compartment for degradation. IDOL is transcriptionally up-regulated by LXR/RXR in response to an increase in intracellular cholesterol.[4] Pharmacologic inhibition of IDOL could reduce plasma LDL cholesterol by increasing plasma LDL receptor density.
Function
The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.[1]
References
- ↑ 1.0 1.1 "Entrez Gene: MYLIP myosin regulatory light chain interacting protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29116.
- ↑ "LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor". Science 325 (5936): 100–4. July 2009. doi:10.1126/science.1168974. PMID 19520913.
- ↑ "Mylip makes an Idol turn into regulation of LDL receptor". Cell. Mol. Life Sci. 66 (21): 3399–402. November 2009. doi:10.1007/s00018-009-0127-y. PMID 19688294.
- ↑ Sawamura, T. (2009). "New Idol for cholesterol reduction?". Clin. Chem. 55 (12): 2082–2084. doi:10.1373/clinchem.2009.134023. PMID 19833835.
Further reading
- "MIR is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.". J. Biol. Chem. 274 (51): 36288–92. 2000. doi:10.1074/jbc.274.51.36288. PMID 10593918.
- "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. 2001. doi:10.1101/gr.140200. PMID 11042152.
- "Neuronal expression of the ERM-like protein MIR in rat brain and its localization to human chromosome 6.". Biochem. Biophys. Res. Commun. 279 (3): 879–83. 2001. doi:10.1006/bbrc.2000.4028. PMID 11162443.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "MSAP is a novel MIR-interacting protein that enhances neurite outgrowth and increases myosin regulatory light chain.". J. Biol. Chem. 278 (37): 35412–20. 2003. doi:10.1074/jbc.M306271200. PMID 12826659.
- "Functional activities and cellular localization of the ezrin, radixin, moesin (ERM) and RING zinc finger domains in MIR.". FEBS Lett. 553 (1–2): 195–9. 2003. doi:10.1016/S0014-5793(03)01010-X. PMID 14550572.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. 2004. doi:10.1073/pnas.0404089101. PMID 15498874.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514.
- "Inhibition of MHC class II expression and immune responses by c-MIR.". J. Immunol. 177 (1): 341–54. 2006. doi:10.4049/jimmunol.177.1.341. PMID 16785530.
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