Biology:Mammaglobin-A

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Mammaglobin-A also known as secretoglobin family 2A member 2 is a protein that in humans is encoded by the SCGB2A2 gene.[1][2][3]

Function

SCGB2A2 is a member of the superfamily of secretoglobins, a group of small dimeric secreted and sometimes glycosylated proteins. Expressed mainly in mucosa, secretoglobins seem to be involved in cell signalling, immune response, and chemotaxis, and may also serve as transporters for steroid hormones in humans.[4]

Clinical significance

SCGB2A2 expression is highly specific of mammary tissue, and is increasingly used for identification and detection of disseminated breast cancer cells.[5]

References

  1. "Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11q13". Oncogene 16 (6): 817–24. Mar 1998. doi:10.1038/sj.onc.1201597. PMID 9488047. 
  2. "Mammaglobin, a mammary-specific member of the uteroglobin gene family, is overexpressed in human breast cancer". Cancer Res 56 (4): 860–5. Jul 1996. PMID 8631025. 
  3. "Entrez Gene: SCGB2A2 secretoglobin, family 2A, member 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4250. 
  4. "Evaluation of expression based markers for the detection of breast cancer cells". Breast Cancer Research and Treatment 97 (1): 41–47. 2006. doi:10.1007/s10549-005-9085-8. PMID 16319979. 
  5. "Significance, detection and markers of disseminated breast cancer cells". Endocrine-Related Cancer (Bioscientifica) 13 (4): 1033–1067. 2006. doi:10.1677/ERC-06-0001. PMID 17158753. 

Further reading