Biology:Metallothionein 1A

Short description: Protein found in humans

Generic protein structure example

Metallothionein-1A is a protein that in humans is encoded by the MT1A gene.

Further reading

• "Metallothionein: an overview.". World Journal of Gastroenterology 13 (7): 993–6. 2007. doi:10.3748/wjg.v13.i7.993. PMID 17373731. 
• "The human metallothionein gene cluster is not disrupted in myelomonocytic leukemia.". Genomics 6 (1): 144–8. 1990. doi:10.1016/0888-7543(90)90459-8. PMID 2303255. 
• "Erythrocyte metallothionein as an index of zinc status in humans.". Proceedings of the National Academy of Sciences of the United States of America 87 (4): 1259–62. 1990. doi:10.1073/pnas.87.4.1259. PMID 2304897. Bibcode: 1990PNAS...87.1259G. 
• "Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia.". Nature 313 (6004): 709–11. 1985. doi:10.1038/313709a0. PMID 3856101. Bibcode: 1985Natur.313..709L. 
• "Isolation and characterization of six human hepatic isometallothioneins.". Biochemical Journal 231 (2): 375–82. 1985. doi:10.1042/bj2310375. PMID 4062903. 
• "Structure elucidation of the metal-binding sites in metallothionein by 113Cd NMR.". Federation Proceedings 41 (13): 2974–80. 1983. PMID 7140998. 
• "Development of an enzyme-linked immunosorbent assay for human metallothionein-1 in plasma and urine.". The Journal of Laboratory and Clinical Medicine 126 (2): 119–27. 1995. PMID 7543551. 
• "Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression.". Journal of Nutrition 128 (5): 825–31. 1998. doi:10.1093/jn/128.5.825. PMID 9566988. 
• "Metallothionein-induced increase in mitochondrial inner membrane permeability.". Journal of Surgical Research 75 (1): 30–4. 1998. doi:10.1006/jsre.1997.5241. PMID 9614853. 
• "Developmental changes in hepatic metallothionein, zinc, and copper levels in genetically altered mice.". Biochemistry and Cell Biology 76 (4): 615–23. 1999. doi:10.1139/bcb-76-4-615. PMID 10099782. 
• "Nuclear import of metallothionein requires its mRNA to be associated with the perinuclear cytoskeleton.". Journal of Biological Chemistry 274 (49): 34961–6. 2000. doi:10.1074/jbc.274.49.34961. PMID 10574972. 
• "Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer.". The Prostate 43 (2): 125–35. 2000. doi:10.1002/(SICI)1097-0045(20000501)43:2<125::AID-PROS7>3.0.CO;2-S. PMID 10754528. 
• "Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion.". The Journal of Neuroscience 20 (14): 5200–7. 2000. doi:10.1523/JNEUROSCI.20-14-05200.2000. PMID 10884303. 
• "Metallothionein isogene transcription in red blood cell precursors from human cord blood.". European Journal of Biochemistry 268 (3): 849–56. 2001. doi:10.1046/j.1432-1327.2001.01947.x. PMID 11168427. 
• "Influence of metallothionein-1 localization on its function.". Biochemical Journal 355 (Pt 2): 473–9. 2001. doi:10.1042/0264-6021:3550473. PMID 11284736. 
• "Speciation analysis of trace elements in the brains of individuals with Alzheimer's disease with special emphasis on metallothioneins.". Analytical and Bioanalytical Chemistry 372 (3): 412–7. 2002. doi:10.1007/s00216-001-1187-5. PMID 11939525. 
• "Determination of metallothionein-1/metallothionein-2 ratios in the mouse liver and pancreas by capillary zone electrophoresis using a polyacrylamide-coated capillary at neutral pH.". Journal of Chromatography B 779 (2): 211–9. 2003. doi:10.1016/S1570-0232(02)00375-6. PMID 12361735.