Biology:Metallothionein 2A
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Short description: Protein found in humans
 Generic protein structure example |
Metallothionein-2 is a metallothionein protein that in humans is encoded by the MT2A gene.[1][2]
The single-nucleotide polymorphism rs28366003 which substitutes guanine for adenine in MT2A is associated with certain cancers and some chronic diseases.[3]
Interactions
Metallothionein 2A has been shown to interact with protein kinase D1.[4]
References
- ↑ "Human metallothionein genes--primary structure of the metallothionein-II gene and a related processed gene". Nature 299 (5886): 797–802. Dec 1982. doi:10.1038/299797a0. PMID 7133118. Bibcode: 1982Natur.299..797K.
- ↑ "Entrez Gene: MT2A metallothionein 2A". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4502.
- ↑ "Metallothionein 2A gene polymorphisms in relation to diseases and trace element levels in humans". Arhiv Za Higijenu Rada I Toksikologiju 71 (1): 27–47. 2020. doi:10.2478/aiht-2020-71-3349. PMID 32597135.
- ↑ Rao, Prema S; Jaggi Meena; Smith David J; Hemstreet George P; Balaji K C (Oct 2003). "Metallothionein 2A interacts with the kinase domain of PKCmu in prostate cancer". Biochem. Biophys. Res. Commun. (United States) 310 (3): 1032–8. doi:10.1016/j.bbrc.2003.09.118. ISSN 0006-291X. PMID 14550308.
Further reading
- "Primary structure of human hepatic metallothionein.". FEBS Lett. 82 (2): 247–50. 1977. doi:10.1016/0014-5793(77)80594-2. PMID 913597.
- "Expression of human metallothionein-II fusion protein in Escherichia coli.". Biochem. Int. 28 (3): 451–60. 1993. PMID 1339282.
- "Comparison of the solution conformations of human [Zn7]-metallothionein-2 and [Cd7]-metallothionein-2 using nuclear magnetic resonance spectroscopy.". J. Mol. Biol. 225 (2): 433–43. 1992. doi:10.1016/0022-2836(92)90930-I. PMID 1593628.
- "Expression of c-fos, c-jun, jun-B, metallothionein and metalloproteinase genes in human chondrocyte.". FEBS Lett. 306 (2–3): 169–72. 1992. doi:10.1016/0014-5793(92)80992-P. PMID 1633872.
- "Three-dimensional structure of human [113Cd7]metallothionein-2 in solution determined by nuclear magnetic resonance spectroscopy.". J. Mol. Biol. 214 (3): 765–79. 1990. doi:10.1016/0022-2836(90)90291-S. PMID 2388267.
- "Changes in brain gene expression shared by scrapie and Alzheimer disease.". Proc. Natl. Acad. Sci. U.S.A. 86 (18): 7260–4. 1989. doi:10.1073/pnas.86.18.7260. PMID 2780570. Bibcode: 1989PNAS...86.7260D.
- "Metal-responsive elements act as positive modulators of human metallothionein-IIA enhancer activity.". Mol. Cell. Biol. 7 (2): 606–13. 1987. doi:10.1128/mcb.7.2.606. PMID 3821726.
- "Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene.". Nature 308 (5959): 513–9. 1984. doi:10.1038/308513a0. PMID 6323998. Bibcode: 1984Natur.308..513K.
- "Chromosomal location of human metallothionein genes: implications for Menkes' disease.". Science 224 (4653): 1104–6. 1984. doi:10.1126/science.6719135. PMID 6719135. Bibcode: 1984Sci...224.1104S.
- "Human metallothionein genes: molecular cloning and sequence analysis of the mRNA.". Nucleic Acids Res. 10 (10): 3165–73. 1982. doi:10.1093/nar/10.10.3165. PMID 6896577.
- "Cloning and sequencing a novel metallothionein I isoform expressed in human reticulocytes.". FEBS Lett. 389 (2): 210–2. 1996. doi:10.1016/0014-5793(96)00587-X. PMID 8766831.
- "Energy-dependent nuclear binding dictates metallothionein localization.". J. Cell. Physiol. 182 (1): 69–76. 1999. doi:10.1002/(SICI)1097-4652(200001)182:1<69::AID-JCP8>3.0.CO;2-9. PMID 10567918.
- "Zinc transfer potentials of the alpha - and beta-clusters of metallothionein are affected by domain interactions in the whole molecule.". Proc. Natl. Acad. Sci. U.S.A. 97 (6): 2503–8. 2000. doi:10.1073/pnas.97.6.2503. PMID 10716985. Bibcode: 2000PNAS...97.2503J.
- "Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer.". Prostate 43 (2): 125–35. 2000. doi:10.1002/(SICI)1097-0045(20000501)43:2<125::AID-PROS7>3.0.CO;2-S. PMID 10754528.
- "Expression of metallothionein II in intestinal metaplasia, dysplasia, and gastric cancer.". Cancer Res. 60 (7): 1995–2001. 2000. PMID 10766190.
- "Interactions of arsenic with human metallothionein-2.". J. Biochem. 132 (2): 217–21. 2003. doi:10.1093/oxfordjournals.jbchem.a003213. PMID 12153718.
- "Prior increase in metallothionein levels is required to prevent doxorubicin cardiotoxicity.". Exp. Biol. Med. (Maywood) 227 (8): 652–7. 2002. doi:10.1177/153537020222700815. PMID 12192109.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages.". Nat. Med. 9 (2): 191–7. 2003. doi:10.1038/nm822. PMID 12539042.
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