Biology:mtDNA control region
| Mitochondrial DNA control region secondary structure A | |
|---|---|
 The consensus secondary structure for all haplotypes of the mtDNA control region. | |
| Identifiers | |
| Symbol | mtDNA ssA |
| Rfam | RF01853 |
| Other data | |
| RNA type | Antisense RNA |
| Domain(s) | Mammalia |
| PDB structures | PDBe |
The mtDNA control region is an area of the mitochondrial genome which is non-coding DNA. This region controls RNA and DNA synthesis.[1] It is the most polymorphic region of the human mtDNA genome,[2] with polymorphism concentrated in hypervariable regions. The average nucleotide diversity in these regions is 1.7%.[3] Despite this variability, an RNA transcript from this region has a conserved secondary structure (pictured) which has been found to be under selective pressure.[4]
The mtDNA control region contains the origin of replication of one strand, and the origin of transcription for both strands.[5] There is also an open reading frame thought to code for 7s ribosomal RNA in humans but not in mice or cows, where it has been deleted.[6]
Distinction from D-loop
The control region and mtDNA D-loop are sometimes used synonymously in the literature;[3] specifically the control region includes the D-loop along with adjacent transcription promoter regions. For this reason, the control region is also known by the acronym DLP, standing for D-Loop and associated Promoters.[7]
Endurance study
mtDNA control region haplotypes have been linked with endurance capacity in human subjects.[8] A 2002 study sequenced the control region of 55 subjects and compared their haplotype with the increase in VO2 max after an eight-week training program. They found that different haplotypes were significantly linked with the subjects' endurance. It was speculated that this was because the control region affects replication and transcription in the mitochondria.[4][8]
See also
References
- ↑ Structure of the Mitochondrial Genome DNA Learning Center, Cold Spring Harbor Laboratory
- ↑ "Population variation of human mtDNA control region sequences detected by enzymatic amplification and sequence-specific oligonucleotide probes". Am. J. Hum. Genet. 48 (2): 370–82. February 1991. PMID 1990843.
- ↑ 3.0 3.1 "Human Mitochondrial DNA Variation and Evolution: Analysis of Nucleotide Sequences from Seven Individuals". Genetics 103 (2): 287–312. February 1983. doi:10.1093/genetics/103.2.287. PMID 6299878. PMC 1219980. http://www.genetics.org/cgi/pmidlookup?view=long&pmid=6299878. Retrieved 2010-07-29.
- ↑ 4.0 4.1 "Evidence for variable selective pressures at a large secondary structure of the human mitochondrial DNA control region". Mol. Biol. Evol. 25 (12): 2759–70. December 2008. doi:10.1093/molbev/msn225. PMID 18845547.
- ↑ "Sequence and organization of the human mitochondrial genome". Nature 290 (5806): 457–65. April 1981. doi:10.1038/290457a0. PMID 7219534. Bibcode: 1981Natur.290..457A.
- ↑ "tRNA punctuation model of RNA processing in human mitochondria". Nature 290 (5806): 470–4. April 1981. doi:10.1038/290470a0. PMID 7219536. Bibcode: 1981Natur.290..470O.
- ↑ "Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication". Science 286 (5440): 774–9. October 1999. doi:10.1126/science.286.5440.774. PMID 10531063.
- ↑ 8.0 8.1 "Polymorphisms in control region of mtDNA relates to individual differences in endurance capacity or trainability". Jpn. J. Physiol. 52 (3): 247–56. June 2002. doi:10.2170/jjphysiol.52.247. PMID 12230801.
Further reading
- Stoneking M (October 2000). "Hypervariable Sites in the mtDNA Control Region Are Mutational Hotspots". Am. J. Hum. Genet. 67 (4): 1029–32. doi:10.1086/303092. PMID 10968778.
- "A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms". Nature 409 (6822): 928–33. February 2001. doi:10.1038/35057149. PMID 11237013.
External links
- EMPOP - the Mitochondrial DNA Control Region Database
- Page for Mitochondrial DNA control region secondary structure A at Rfam
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