Biology:Multivesicular release
From HandWiki
Multivesicular release (MVR) is the phenomenon by which individual chemical synapses, forming the junction between neurons, is mediated by multiple releasable vesicles of neurotransmitter.[1] In neuroscience, it is a subject of debate whether one or many vesicles are released per action potential.[2]
Examples
In the mammalian brain, MVR has been shown to be common in CA1 pyramidal cells and Schaffer collateral cells.[2] It has also been proposed[3] and then refuted[4] at the ribbon synapses formed between inner hair cell and spiral ganglion neurons.[5] Recent evidence points to a possibility of MVR at neocortical connections of the somatosensory cortex.[6]
References
- ↑ Tong, G; Jahr, CE (January 1994). "Multivesicular release from excitatory synapses of cultured hippocampal neurons.". Neuron 12 (1): 51–9. doi:10.1016/0896-6273(94)90151-1. PMID 7507341.
- ↑ 2.0 2.1 Christie, JM; Jahr, CE (4 January 2006). "Multivesicular release at Schaffer collateral-CA1 hippocampal synapses.". The Journal of Neuroscience 26 (1): 210–6. doi:10.1523/jneurosci.4307-05.2006. PMID 16399689.
- ↑ Glowatzki, E; Fuchs, PA (February 2002). "Transmitter release at the hair cell ribbon synapse.". Nature Neuroscience 5 (2): 147–54. doi:10.1038/nn796. PMID 11802170.
- ↑ "Uniquantal release through a dynamic fusion pore is a candidate mechanism of hair cell exocytosis". Neuron 83 (6): 1389–403. 2014. doi:10.1016/j.neuron.2014.08.003. PMID 25199706.
- ↑ Fuchs, PA (1 July 2005). "Time and intensity coding at the hair cell's ribbon synapse.". The Journal of Physiology 566 (Pt 1): 7–12. doi:10.1113/jphysiol.2004.082214. PMID 15845587.
- ↑ Huang, CH; Bao, J; Sakaba, T (8 September 2010). "Multivesicular release differentiates the reliability of synaptic transmission between the visual cortex and the somatosensory cortex.". The Journal of Neuroscience 30 (36): 11994–2004. doi:10.1523/jneurosci.2381-10.2010. PMID 20826663.
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