Biology:Myosin-2

Generic protein structure example

Myosin-2 (myosin heavy chain 2) is a protein that in humans is encoded by the MYH2 gene.

Further reading

• "A polymorphic human myosin heavy chain locus is linked to an anonymous single copy locus (D17S1) at 17p13.". Cytogenet. Cell Genet. 43 (1–2): 117–20. 1987. doi:10.1159/000132307. PMID 2877813. 
• "Characterization of human skeletal muscle fibres according to the myosin heavy chains they express". J. Muscle Res. Cell. Motil. 16 (1): 35–43. 1995. doi:10.1007/BF00125308. PMID 7751403. 
• "Control of AMP deaminase 1 binding to myosin heavy chain". Am. J. Physiol. 275 (3 Pt 1): C870–81. 1998. doi:10.1152/ajpcell.1998.275.3.C870. PMID 9730972. 
• "Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2958–63. 1999. doi:10.1073/pnas.96.6.2958. PMID 10077619. Bibcode: 1999PNAS...96.2958W. 
• "Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity". J. Mol. Biol. 290 (1): 61–75. 1999. doi:10.1006/jmbi.1999.2865. PMID 10388558. 
• "Effects of bone fracture and surgery on plasma myosin heavy chain fragments of skeletal muscle". Clinical and Investigative Medicine 22 (5): 180–4. 1999. PMID 10579056. 
• "Autosomal dominant myopathy: missense mutation (Glu-706 --> Lys) in the myosin heavy chain IIa gene". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14614–9. 2001. doi:10.1073/pnas.250289597. PMID 11114175. 
• "Myosin heavy chain IIa gene mutation E706K is pathogenic and its expression increases with age". Neurology 58 (5): 780–6. 2002. doi:10.1212/wnl.58.5.780. PMID 11889243. 
• "PKC epsilon is associated with myosin IIA and actin in fibroblasts". Cell. Signal. 14 (6): 529–36. 2002. doi:10.1016/S0898-6568(01)00277-7. PMID 11897493. 
• "Intracellular calcium and myosin isoform transitions. Calcineurin and calcium-calmodulin kinase pathways regulate preferential activation of the IIa myosin heavy chain promoter". J. Biol. Chem. 277 (47): 45323–30. 2003. doi:10.1074/jbc.M208302200. PMID 12235157. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Characterization of the metastasis-associated protein, S100A4. Roles of calcium binding and dimerization in cellular localization and interaction with myosin". J. Biol. Chem. 278 (32): 30063–73. 2003. doi:10.1074/jbc.M304909200. PMID 12756252. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "IRF-2 is involved in up-regulation of nonmuscle myosin heavy chain II-A gene expression during phorbol ester-induced promyelocytic HL-60 differentiation". J. Biol. Chem. 279 (53): 56042–52. 2005. doi:10.1074/jbc.M404791200. PMID 15496418. 
• "Mutations and sequence variation in the human myosin heavy chain IIa gene (MYH2)". Eur. J. Hum. Genet. 13 (5): 617–22. 2005. doi:10.1038/sj.ejhg.5201375. PMID 15741996. 
• "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560. 
• "Muscle cell and motor protein function in patients with a IIa myosin missense mutation (Glu-706 to Lys)". Neuromuscul. Disord. 16 (11): 782–91. 2006. doi:10.1016/j.nmd.2006.07.023. PMID 17005402. 
• "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.