Biology:NACA (gene)

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Short description: Protein-coding gene in humans


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Nascent-polypeptide-associated complex alpha polypeptide, also known as NACA, is a protein which in humans is encoded by the NACA gene.[1][2][3]

Function

NACA prevents short recently synthesized (i.e., nascent) ribosome-associated polypeptides from inappropriate interactions with cytosolic proteins. NACA binds nascent-polypeptide domains emerging from ribosomes unless it contains a signal peptide which is fully exposed. Depletion of NACA from ribosomes carrying nascent polypeptides allows the signal recognition particle (SRP) to crosslink to polypeptides regardless of whether or not they contain signal peptides or not. In the absence of NACA, proteins lacking signal peptides can be mis-translocated into the endoplasmic reticulum.[2][4]

The NACA protein is expressed in bone during development and acts as a transcriptional coactivator in conjunction with acidic activators.[3]

Interactions

NACA has been shown to interact with BTF3, FADD,[5] C-jun,[6] and 3 members of taxilin family.[7]

References

  1. "Entrez Gene: NACA nascent-polypeptide-associated complex alpha polypeptide". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4666. 
  2. 2.0 2.1 "A protein complex required for signal-sequence-specific sorting and translocation". Nature 370 (6489): 434–40. August 1994. doi:10.1038/370434a0. PMID 8047162. Bibcode1994Natur.370..434W. 
  3. 3.0 3.1 "Mapping of the human gene for the alpha-NAC/1.9.2 (NACA/1.9.2) transcriptional coactivator to Chromosome 12q23-24.1". Mamm. Genome 7 (2): 163–4. February 1996. doi:10.1007/BF03035343. PMID 8835540. http://link.springer-ny.com/link/service/journals/00335/bibs/7n2p163.html. 
  4. "Nascent-polypeptide-associated complex". Cell. Mol. Life Sci. 59 (10): 1632–9. October 2002. doi:10.1007/PL00012490. PMID 12475173. https://link.springer.com/article/10.1007%2FPL00012490. 
  5. "The alpha-chain of the nascent polypeptide-associated complex binds to and regulates FADD function". Biochem. Biophys. Res. Commun. 303 (4): 1034–41. April 2003. doi:10.1016/S0006-291X(03)00487-X. PMID 12684039. 
  6. "Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcription". Mol. Cell. Biol. 18 (3): 1312–21. March 1998. doi:10.1128/MCB.18.3.1312. PMID 9488446. 
  7. "Interaction of the taxilin family with the nascent polypeptide-associated complex that is involved in the transcriptional and translational processes". Genes Cells 10 (5): 465–76. May 2005. doi:10.1111/j.1365-2443.2005.00848.x. PMID 15836775. 

Further reading