Biology:NACA (gene)
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Short description: Protein-coding gene in humans
 Generic protein structure example |
Nascent-polypeptide-associated complex alpha polypeptide, also known as NACA, is a protein which in humans is encoded by the NACA gene.[1][2][3]
Function
NACA prevents short recently synthesized (i.e., nascent) ribosome-associated polypeptides from inappropriate interactions with cytosolic proteins. NACA binds nascent-polypeptide domains emerging from ribosomes unless it contains a signal peptide which is fully exposed. Depletion of NACA from ribosomes carrying nascent polypeptides allows the signal recognition particle (SRP) to crosslink to polypeptides regardless of whether or not they contain signal peptides or not. In the absence of NACA, proteins lacking signal peptides can be mis-translocated into the endoplasmic reticulum.[2][4]
The NACA protein is expressed in bone during development and acts as a transcriptional coactivator in conjunction with acidic activators.[3]
Interactions
NACA has been shown to interact with BTF3, FADD,[5] C-jun,[6] and 3 members of taxilin family.[7]
References
- ↑ "Entrez Gene: NACA nascent-polypeptide-associated complex alpha polypeptide". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4666.
- ↑ 2.0 2.1 "A protein complex required for signal-sequence-specific sorting and translocation". Nature 370 (6489): 434–40. August 1994. doi:10.1038/370434a0. PMID 8047162. Bibcode: 1994Natur.370..434W.
- ↑ 3.0 3.1 "Mapping of the human gene for the alpha-NAC/1.9.2 (NACA/1.9.2) transcriptional coactivator to Chromosome 12q23-24.1". Mamm. Genome 7 (2): 163–4. February 1996. doi:10.1007/BF03035343. PMID 8835540. http://link.springer-ny.com/link/service/journals/00335/bibs/7n2p163.html.
- ↑ "Nascent-polypeptide-associated complex". Cell. Mol. Life Sci. 59 (10): 1632–9. October 2002. doi:10.1007/PL00012490. PMID 12475173. https://link.springer.com/article/10.1007%2FPL00012490.
- ↑ "The alpha-chain of the nascent polypeptide-associated complex binds to and regulates FADD function". Biochem. Biophys. Res. Commun. 303 (4): 1034–41. April 2003. doi:10.1016/S0006-291X(03)00487-X. PMID 12684039.
- ↑ "Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcription". Mol. Cell. Biol. 18 (3): 1312–21. March 1998. doi:10.1128/MCB.18.3.1312. PMID 9488446.
- ↑ "Interaction of the taxilin family with the nascent polypeptide-associated complex that is involved in the transcriptional and translational processes". Genes Cells 10 (5): 465–76. May 2005. doi:10.1111/j.1365-2443.2005.00848.x. PMID 15836775.
Further reading
- "A protein complex required for signal-sequence-specific sorting and translocation.". Nature 370 (6489): 434–40. 1994. doi:10.1038/370434a0. PMID 8047162. Bibcode: 1994Natur.370..434W.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Mapping of the human gene for the alpha-NAC/1.9.2 (NACA/1.9.2) transcriptional coactivator to Chromosome 12q23-24.1.". Mamm. Genome 7 (2): 163–4. 1996. doi:10.1007/BF03035343. PMID 8835540.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "The alpha chain of the nascent polypeptide-associated complex functions as a transcriptional coactivator.". Mol. Cell. Biol. 18 (3): 1303–11. 1998. doi:10.1128/MCB.18.3.1303. PMID 9488445.
- "Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcription.". Mol. Cell. Biol. 18 (3): 1312–21. 1998. doi:10.1128/MCB.18.3.1312. PMID 9488446.
- "Cloning of novel injury-regulated genes. Implications for an important role of the muscle-specific protein skNAC in muscle repair.". J. Biol. Chem. 274 (19): 13305–10. 1999. doi:10.1074/jbc.274.19.13305. PMID 10224091.
- "The alpha and beta subunit of the nascent polypeptide-associated complex have distinct functions.". J. Biol. Chem. 275 (48): 37838–45. 2001. doi:10.1074/jbc.M006368200. PMID 10982809.
- "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546–60. 2001. doi:10.1101/gr.140200. PMID 11042152.
- "m-Bop, a repressor protein essential for cardiogenesis, interacts with skNAC, a heart- and muscle-specific transcription factor.". J. Biol. Chem. 277 (29): 26524–9. 2002. doi:10.1074/jbc.M204121200. PMID 12011100.
- "Human brain nascent polypeptide-associated complex alpha subunit is decreased in patients with Alzheimer' s disease and Down syndrome.". J. Investig. Med. 50 (4): 293–301. 2002. PMID 12109594. https://jim.bmj.com/lookup/pmidlookup?view=long&pmid=12109594.
- "Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library.". Int. J. Cancer 100 (6): 669–77. 2002. doi:10.1002/ijc.10550. PMID 12209604.
- "Characterization of a novel isoform of alpha-nascent polypeptide-associated complex as IgE-defined autoantigen.". J. Invest. Dermatol. 119 (4): 820–9. 2002. doi:10.1046/j.1523-1747.2002.00518.x. PMID 12406326.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The alpha-chain of the nascent polypeptide-associated complex binds to and regulates FADD function.". Biochem. Biophys. Res. Commun. 303 (4): 1034–41. 2003. doi:10.1016/S0006-291X(03)00487-X. PMID 12684039.
- "Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas.". Bone 32 (4): 364–71. 2003. doi:10.1016/S8756-3282(03)00026-7. PMID 12689679.
- "Expression analysis of alpha-NAC and ANX2 in juvenile myelomonocytic leukemia using SMART polymerase chain reaction and "virtual Northern" hybridization.". Cancer Genet. Cytogenet. 142 (2): 149–52. 2003. doi:10.1016/S0165-4608(02)00841-5. PMID 12699894.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Investigation of alpha nascent polypeptide-associated complex functions in a human CD8(+) T cell ex vivo expansion model using antisense oligonucleotides.". Immunology 112 (3): 397–403. 2004. doi:10.1111/j.1365-2567.2004.01893.x. PMID 15196207.
- "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell. Proteomics 3 (11): 1093–101. 2005. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
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