Biology:NAPSA
 Generic protein structure example |
Napsin-A is an aspartic proteinase that is encoded in humans by the NAPSA gene.[1] The name napsin comes from novel aspartic proteinase of the pepsin family.[2]
The activation peptide of an aspartic proteinase acts as an inhibitor of the active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The pronapsin A gene is expressed predominantly in lung and kidney. Its translation product is predicted to be a fully functional, glycosylated aspartic proteinase precursor containing an RGD motif and an additional 18 residues at its C-terminus.[1]
Utility
Detection of NAPSA gene expression can be used to distinguish adenocarcinomas from other forms of lung cancer.[3]
References
- ↑ 1.0 1.1 "Entrez Gene: NAPSA napsin A aspartic peptidase". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9476.
- ↑ Tatnell, Peter J; Powell, David J; Hill, Jeffrey; Smith, Trudi S; Tew, David G; Kay, John (11 December 1998). "Napsins: new human aspartic proteinases". FEBS Letters 441 (1): 43–48. doi:10.1016/s0014-5793(98)01522-1. PMID 9877162.
- ↑ "Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma.". Br. J. Cancer 88 (8): 1229–33. 2004. doi:10.1038/sj.bjc.6600879. PMID 12698189.
Further reading
- "Multiple functions of pro-parts of aspartic proteinase zymogens.". FEBS Lett. 343 (1): 6–10. 1994. doi:10.1016/0014-5793(94)80596-2. PMID 8163018.
- The aspartic proteinases. An historical overview.. Adv. Exp. Med. Biol.. 436. 1998. pp. 1–13. doi:10.1007/978-1-4615-5373-1_1.
- "Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas.". FEBS Lett. 462 (1–2): 129–34. 2000. doi:10.1016/S0014-5793(99)01493-3. PMID 10580105.
- "Human napsin A: expression, immunochemical detection, and tissue localization.". FEBS Lett. 462 (1–2): 135–9. 2000. doi:10.1016/S0014-5793(99)01458-1. PMID 10580106.
- "Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.". Nature 402 (6761): 533–7. 1999. doi:10.1038/990107. PMID 10591213. Bibcode: 1999Natur.402..533Y.
- "Pronapsin A and B gene expression in normal and malignant human lung and mononuclear blood cells.". Biochim. Biophys. Acta 1577 (1): 10–6. 2002. doi:10.1016/s0167-4781(02)00400-1. PMID 12151090.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung.". J. Biol. Chem. 278 (49): 49006–14. 2004. doi:10.1074/jbc.M306844200. PMID 13129928.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Abi1 is essential for the formation and activation of a WAVE2 signalling complex.". Nat. Cell Biol. 6 (4): 319–27. 2004. doi:10.1038/ncb1105. PMID 15048123.
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