Biology:NCAPG2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Condensin-2 complex subunit G2 (CAP-G2) also known as chromosome-associated protein G2 (CAP-G2) or leucine zipper protein 5 (LUZP5) is a protein that in humans is encoded by the NCAPG2 gene.[1][2] CAP-G2 is a subunit of condensin II, a large protein complex involved in chromosome condensation. It interacts with PLK1 through its C-terminal region during mitosis[3]
Clinical importance
Mutations in this gene in humans have been associated with severe neurodevelopmental defects, failure to thrive, ocular abnormalities, and defects in urogenital and limb morphogenesis.[4]
References
- ↑ "Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells". Cell 115 (1): 109–21. October 2003. doi:10.1016/S0092-8674(03)00724-4. PMID 14532007.
- ↑ "Entrez Gene: NCAPG2 non-SMC condensin II complex, subunit G2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54892.
- ↑ "The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores". Nature Communications 5: 4588. August 2014. doi:10.1038/ncomms5588. PMID 25109385. Bibcode: 2014NatCo...5.4588K.
- ↑ "Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies". American Journal of Human Genetics 104 (1): 94–111. January 2019. doi:10.1016/j.ajhg.2018.11.017. PMID 30609410.
Further reading
- "More than blood, a novel gene required for mammalian postimplantation development". Molecular and Cellular Biology 24 (3): 1168–73. February 2004. doi:10.1128/MCB.24.3.1168-1173.2004. PMID 14729962.
- "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America 103 (14): 5391–6. April 2006. doi:10.1073/pnas.0507066103. PMID 16565220. Bibcode: 2006PNAS..103.5391N.
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