Biology:NCKIPSD
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
NCK-interacting protein with SH3 domain is a protein that in humans is encoded by the NCKIPSD gene.[1][2][3]
The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing occurs in this locus and two transcript variants encoding distinct isoforms have been identified.[3]
Interactions
NCKIPSD has been shown to interact with Grb2[4][5] and NCK1.[6]
References
- ↑ "Novel SH3 protein encoded by the AF3p21 gene is fused to the mixed lineage leukemia protein in a therapy-related leukemia with t(3;11) (p21;q23)". Blood 95 (3): 1066–8. February 2000. doi:10.1182/blood.V95.3.1066.003k11_1066_1068. PMID 10648423.
- ↑ "The VacA toxin of Helicobacter pylori identifies a new intermediate filament-interacting protein". The EMBO Journal 19 (1): 48–56. January 2000. doi:10.1093/emboj/19.1.48. PMID 10619843.
- ↑ 3.0 3.1 "Entrez Gene: NCKIPSD NCK interacting protein with SH3 domain". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51517.
- ↑ "mDia-interacting protein acts downstream of Rho-mDia and modifies Src activation and stress fiber formation". The Journal of Biological Chemistry 276 (42): 39290–4. October 2001. doi:10.1074/jbc.M107026200. PMID 11509578.
- ↑ "A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42". The Journal of Cell Biology 152 (3): 471–82. February 2001. doi:10.1083/jcb.152.3.471. PMID 11157975.
- ↑ "SPIN90 (SH3 protein interacting with Nck, 90 kDa), an adaptor protein that is developmentally regulated during cardiac myocyte differentiation". The Journal of Biological Chemistry 276 (16): 12871–8. April 2001. doi:10.1074/jbc.M009411200. PMID 11278500.
Further reading
- "A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42". The Journal of Cell Biology 152 (3): 471–82. February 2001. doi:10.1083/jcb.152.3.471. PMID 11157975.
- "Genomic organization, tissue expression, and cellular localization of AF3p21, a fusion partner of MLL in therapy-related leukemia". Genes, Chromosomes & Cancer 30 (4): 364–74. April 2001. doi:10.1002/gcc.1102. PMID 11241789.
- "SPIN90 (SH3 protein interacting with Nck, 90 kDa), an adaptor protein that is developmentally regulated during cardiac myocyte differentiation". The Journal of Biological Chemistry 276 (16): 12871–8. April 2001. doi:10.1074/jbc.M009411200. PMID 11278500.
- "mDia-interacting protein acts downstream of Rho-mDia and modifies Src activation and stress fiber formation". The Journal of Biological Chemistry 276 (42): 39290–4. October 2001. doi:10.1074/jbc.M107026200. PMID 11509578.
- "Regulation of SPIN90 phosphorylation and interaction with Nck by ERK and cell adhesion". The Journal of Biological Chemistry 278 (52): 52116–23. December 2003. doi:10.1074/jbc.M310974200. PMID 14559906.
- "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology 14 (16): 1436–50. August 2004. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Interaction of SPIN90 with the Arp2/3 complex mediates lamellipodia and actin comet tail formation". The Journal of Biological Chemistry 281 (1): 617–25. January 2006. doi:10.1074/jbc.M504450200. PMID 16253999.
- "Dia-interacting protein modulates formin-mediated actin assembly at the cell cortex". Current Biology 17 (7): 579–91. April 2007. doi:10.1016/j.cub.2007.03.024. PMID 17398099.
- "Palladin interacts with SH3 domains of SPIN90 and Src and is required for Src-induced cytoskeletal remodeling". Experimental Cell Research 313 (12): 2575–85. July 2007. doi:10.1016/j.yexcr.2007.04.030. PMID 17537434.
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