Biology:NELL2
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Short description: Protein-coding gene in the species Homo sapiens
![]() Generic protein structure example |
Protein kinase C-binding protein NELL2 is an enzyme that in humans is encoded by the NELL2 gene.[1]
This gene encodes a cytoplasmic protein that contains epidermal growth factor (EGF) -like repeats. The encoded heterotrimeric protein may be involved in cell growth regulation and differentiation. A similar protein in rodents is involved in craniosynostosis. An alternative splice variant has been described but its full length sequence has not been determined.[1]
References
Further reading
- "Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats.". Genomics 38 (3): 273–6. 1997. doi:10.1006/geno.1996.0628. PMID 8975702.
- "Merging extracellular domains: fold prediction for laminin G-like and amino-terminal thrombospondin-like modules based on homology to pentraxins.". J. Mol. Biol. 275 (5): 725–30. 1998. doi:10.1006/jmbi.1997.1510. PMID 9480764.
- "The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage.". Gene 231 (1–2): 121–6. 1999. doi:10.1016/S0378-1119(99)00093-1. PMID 10231576.
- "Biochemical characterization and expression analysis of neural thrombospondin-1-like proteins NELL1 and NELL2". Biochem. Biophys. Res. Commun. 265 (1): 79–86. 1999. doi:10.1006/bbrc.1999.1638. PMID 10548494.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. 2005. doi:10.1110/ps.04682504. PMID 15340161.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
![]() | Original source: https://en.wikipedia.org/wiki/NELL2.
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