Biology:NEURL2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Neuralized-like protein 2 is a protein that in humans is encoded by the NEURL2 gene.[1][2]
Function
This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis.[2]
See also
- NEURL (gene)
References
- ↑ "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci 27 (5): 235–41. Jun 2002. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
- ↑ 2.0 2.1 "Entrez Gene: NEURL2 neuralized homolog 2 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=140825.
Further reading
- Song R; Koo BK; Yoon KJ; Yoon, M.-J.; Yoo, K.-W.; Kim, H.-T.; Oh, H.-J.; Kim, Y.-Y. et al. (2007). "Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1". J. Biol. Chem. 281 (47): 36391–400. doi:10.1074/jbc.M606601200. PMID 17003037.
- Gerhard DS; Wagner L; Feingold EA; Shenmen, CM; Grouse, LH; Schuler, G; Klein, SL; Old, S et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Nastasi T; Bongiovanni A; Campos Y; Mann, Linda; Toy, James N; Bostrom, Jake; Rottier, Robbert; Hahn, Christopher et al. (2004). "Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis". Dev. Cell 6 (2): 269–82. doi:10.1016/S1534-5807(04)00020-6. PMID 14960280.
- Ota T; Suzuki Y; Nishikawa T; Otsuki, Tetsuji; Sugiyama, Tomoyasu; Irie, Ryotaro; Wakamatsu, Ai; Hayashi, Koji et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Strausberg RL; Feingold EA; Grouse LH; Derge, JG; Klausner, RD; Collins, FS; Wagner, L; Shenmen, CM et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Deloukas P; Matthews LH; Ashurst J; Burton, J.; Gilbert, J. G. R.; Jones, M.; Stavrides, G.; Almeida, J. P. et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. Bibcode: 2001Natur.414..865D.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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