Biology:NKRF (gene)
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
NF-kappa-B-repressing factor is a protein that in humans is encoded by the NKRF gene.[1][2]
This gene encodes a transcription factor that interacts with specific negative regulatory elements (NREs) to mediate transcriptional repression of certain NK-kappa-B-responsive genes.
The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm.[2]
References
- ↑ "Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB". EMBO J 18 (22): 6415–25. Jan 2000. doi:10.1093/emboj/18.22.6415. PMID 10562553.
- ↑ 2.0 2.1 "Entrez Gene: NKRF NF-kappaB repressing factor". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55922.
Further reading
- "Identification of a new member (ZNF183) of the Ring finger gene family in Xq24-25". Gene 192 (2): 291–8. 1997. doi:10.1016/S0378-1119(97)00108-X. PMID 9224902.
- "Identification of a negative response element in the human inducible nitric-oxide synthase (hiNOS) promoter: The role of NF-kappa B-repressing factor (NRF) in basal repression of the hiNOS gene". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14212–7. 2002. doi:10.1073/pnas.212306199. PMID 12381793. Bibcode: 2002PNAS...9914212F.
- "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell 13 (11): 4100–9. 2003. doi:10.1091/mbc.E02-05-0271. PMID 12429849.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Cloning of the correct full length cDNA of NF-kappaB-repressing factor". Mol. Cells 16 (3): 397–401. 2004. PMID 14744032.
- "Nucleolar localization and mobility analysis of the NF-kappaB repressing factor NRF". J. Cell Sci. 117 (Pt 16): 3447–58. 2005. doi:10.1242/jcs.01129. PMID 15226370.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "NF-kappaB-repressing factor inhibits elongation of human immunodeficiency virus type 1 transcription by DRB sensitivity-inducing factor". Mol. Cell. Biol. 25 (17): 7473–83. 2005. doi:10.1128/MCB.25.17.7473-7483.2005. PMID 16107696.
- "Role of IKK and oscillatory NFkappaB kinetics in MMP-9 gene expression and chemoresistance to 5-fluorouracil in RKO colorectal cancer cells". Mol. Carcinog. 46 (5): 402–13. 2007. doi:10.1002/mc.20288. PMID 17186550.
- "NRF IRES activity is mediated by RNA binding protein JKTBP1 and a 14-nt RNA element". RNA 13 (8): 1328–40. 2007. doi:10.1261/rna.545407. PMID 17592041.
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