Biology:NLGN1
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Neuroligin-1 is a protein that in humans is encoded by the NLGN1 gene.[1][2][3]
This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligin-1 acts as splice site-specific ligand for β-neurexins and has been shown to localize to the postsynaptic compartment at excitatory synapses and is involved in the formation and remodeling of central nervous system synapses.[3][4]
Interactions
NLGN1 has been shown to interact with NRXN1[5][6] and DLG4.[7]
See also
- Neurexins: NRXN1, NRXN2, NRXN3
References
- ↑ "The structure and expression of the human neuroligin-3 gene". Gene 246 (1–2): 303–10. April 2000. doi:10.1016/S0378-1119(00)00049-4. PMID 10767552.
- ↑ "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 7 (2): 143–50. April 2000. doi:10.1093/dnares/7.2.143. PMID 10819331.
- ↑ 3.0 3.1 "Entrez Gene: NLGN1 neuroligin 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22871.
- ↑ "Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons". Cell 101 (6): 657–69. June 2000. doi:10.1016/S0092-8674(00)80877-6. PMID 10892652.
- ↑ "Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta". The Journal of Biological Chemistry 278 (50): 50497–505. December 2003. doi:10.1074/jbc.M306803200. PMID 14522992.
- ↑ "Structures, alternative splicing, and neurexin binding of multiple neuroligins". The Journal of Biological Chemistry 271 (5): 2676–82. February 1996. doi:10.1074/jbc.271.5.2676. PMID 8576240.
- ↑ "Binding of neuroligins to PSD-95". Science 277 (5331): 1511–5. September 1997. doi:10.1126/science.277.5331.1511. PMID 9278515.
Further reading
- "Synapse formation: if it looks like a duck and quacks like a duck ..". Current Biology 10 (17): R620–3. September 2000. doi:10.1016/S0960-9822(00)00663-1. PMID 10996085.
- "Neuroligin 1: a splice site-specific ligand for beta-neurexins". Cell 81 (3): 435–43. May 1995. doi:10.1016/0092-8674(95)90396-8. PMID 7736595.
- "Structures, alternative splicing, and neurexin binding of multiple neuroligins". The Journal of Biological Chemistry 271 (5): 2676–82. February 1996. doi:10.1074/jbc.271.5.2676. PMID 8576240.
- "Binding of neuroligins to PSD-95". Science 277 (5331): 1511–5. September 1997. doi:10.1126/science.277.5331.1511. PMID 9278515.
- "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 6 (3): 197–205. June 1999. doi:10.1093/dnares/6.3.197. PMID 10470851.
- "Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons". Cell 101 (6): 657–69. June 2000. doi:10.1016/S0092-8674(00)80877-6. PMID 10892652.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences of the United States of America 99 (26): 16899–903. December 2002. doi:10.1073/pnas.242603899. PMID 12477932.
- "Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta". The Journal of Biological Chemistry 278 (50): 50497–505. December 2003. doi:10.1074/jbc.M306803200. PMID 14522992.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nature Genetics 36 (1): 40–5. January 2004. doi:10.1038/ng1285. PMID 14702039.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Research 14 (10B): 2121–7. October 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism". The Journal of Biological Chemistry 280 (23): 22365–74. June 2005. doi:10.1074/jbc.M410723200. PMID 15797875.
- "The DNA sequence, annotation and analysis of human chromosome 3". Nature 440 (7088): 1194–8. April 2006. doi:10.1038/nature04728. PMID 16641997.
- "Solution structure of GOPC PDZ domain and its interaction with the C-terminal motif of neuroligin". Protein Science 15 (9): 2149–58. September 2006. doi:10.1110/ps.062087506. PMID 16882988.
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