Biology:NOL6
From HandWiki
 Generic protein structure example |
Nucleolar protein 6 is a protein that in humans is encoded by the NOL6 gene.[1][2][3]
The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified.[3]
References
- ↑ "Isolation and characterization of a new nucleolar protein, Nrap, that is conserved from yeast to humans". Genes Cells 7 (2): 115–32. Mar 2002. doi:10.1046/j.1356-9597.2001.00507.x. PMID 11895476.
- ↑ "The small-subunit processome is a ribosome assembly intermediate". Eukaryot Cell 3 (6): 1619–26. Dec 2004. doi:10.1128/EC.3.6.1619-1626.2004. PMID 15590835.
- ↑ 3.0 3.1 "Entrez Gene: NOL6 nucleolar protein family 6 (RNA-associated)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=65083.
Further reading
- "Directed proteomic analysis of the human nucleolus.". Curr. Biol. 12 (1): 1–11. 2002. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
- "Functional proteomic analysis of human nucleolus.". Mol. Biol. Cell 13 (11): 4100–9. 2003. doi:10.1091/mbc.E02-05-0271. PMID 12429849.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. 2004. doi:10.1038/nature02465. PMID 15164053. Bibcode: 2004Natur.429..369H.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. 2005. doi:10.1038/nature03207. PMID 15635413. Bibcode: 2005Natur.433...77A.
- "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. 2006. doi:10.1073/pnas.0507066103. PMID 16565220. Bibcode: 2006PNAS..103.5391N.
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