Biology:NUTF2

Nuclear transport factor 2 is a protein that in humans is encoded by the NUTF2 gene.^[1]^[2]^[3]

Function

The protein encoded by this gene is a cytosolic factor that facilitates protein transport into the nucleus. It interacts with the nuclear pore complex glycoprotein p62. This encoded protein acts at a relative late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. It is thought to be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.^[3]

Interactions

NUTF2 has been shown to interact with Nucleoporin 62^[1]{^[4] and RAN.^[5]^[6]

References

↑ ^1.0 ^1.1 "Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62". J Cell Biol 129 (4): 925–937. Jun 1995. doi:10.1083/jcb.129.4.925. PMID 7744965.
↑ "Isolation of cDNA coding for the placental protein 15 (PP15)". Nucleic Acids Res 16 (10): 4721. Jul 1988. doi:10.1093/nar/16.10.4721. PMID 3380696.
↑ ^3.0 ^3.1 "Entrez Gene: NUTF2 nuclear transport factor 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10204.
↑ "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins". J. Cell Biol. 134 (3): 589–601. Aug 1996. doi:10.1083/jcb.134.3.589. PMID 8707840.
↑ "Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2". J. Mol. Biol. 344 (2): 303–310. Nov 2004. doi:10.1016/j.jmb.2004.09.043. PMID 15522285.
↑ "Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran". J. Mol. Biol. 277 (3): 635–646. Apr 1998. doi:10.1006/jmbi.1997.1602. PMID 9533885.

"HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr". Mol. Med. 4 (3): 138–43. 1998. doi:10.1007/BF03401911. PMID 9562972.
"Insights into the molecular mechanism of nuclear trafficking using nuclear transport factor 2 (NTF2)". Cell Struct. Funct. 25 (4): 217–225. 2001. doi:10.1247/csf.25.217. PMID 11129791.
"[New placental protein (PP15) with immunosuppressive properties (author's transl)]". Arch. Gynecol. 230 (2): 167–72. 1981. doi:10.1007/BF02108272. PMID 7458421.
"Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins". J. Cell Biol. 134 (3): 589–601. 1996. doi:10.1083/jcb.134.3.589. PMID 8707840.
"The 1.6 angstroms resolution crystal structure of nuclear transport factor 2 (NTF2)". J. Mol. Biol. 260 (3): 422–431. 1996. doi:10.1006/jmbi.1996.0411. PMID 8757804.
"Nuclear protein import is decreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not bind GDP-Ran". J. Mol. Biol. 272 (5): 716–730. 1997. doi:10.1006/jmbi.1997.1255. PMID 9368653.
"Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran". J. Mol. Biol. 277 (3): 635–646. 1998. doi:10.1006/jmbi.1997.1602. PMID 9533885.
"NTF2 mediates nuclear import of Ran". EMBO J. 17 (22): 6587–6598. 1999. doi:10.1093/emboj/17.22.6587. PMID 9822603.
"Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran". Mol. Biol. Cell 11 (2): 703–19. 2000. doi:10.1091/mbc.11.2.703. PMID 10679025.
"Identification of nuclear-import and cell-cycle regulatory proteins that bind to prothymosin alpha". Biochem. Cell Biol. 79 (2): 123–131. 2001. doi:10.1139/bcb-79-2-123. PMID 11310559.
"Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2". J. Mol. Biol. 344 (2): 303–310. 2004. doi:10.1016/j.jmb.2004.09.043. PMID 15522285.
"Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. 2005. doi:10.1038/nature04209. PMID 16189514.