Biology:NadA RNA motif
From HandWiki
| nadA | |
|---|---|
 Consensus secondary structure and sequence conservation of nadA RNA | |
| Identifiers | |
| Symbol | nadA |
| Rfam | RF03013 |
| Other data | |
| RNA type | Gene; sRNA |
| SO | 0001263 |
| PDB structures | PDBe |
The nadA RNA motif is a conserved RNA structure that was discovered by bioinformatics.[1] The nadA motif is found in Acidobacteriota.
nadA RNAs are usually located upstream of nadA genes, which encode quinolinate synthetase, an enzyme that performs a step in NAD synthesis. However, two nadA RNAs are not upstream of a protein-coding gene. Therefore, it is unclear whether nadA RNAs are likely to function as cis-regulatory elements or as small RNAs. These is also evidence that this motif acts as a riboswitch for the enzyme cofactor NAD+.[2]
References
- ↑ "Detection of 224 candidate structured RNAs by comparative analysis of specific subsets of intergenic regions". Nucleic Acids Res. 45 (18): 10811–10823. October 2017. doi:10.1093/nar/gkx699. PMID 28977401.
- ↑ Malkowski, Sarah N.; Spencer, Tara C. J.; Breaker, Ronald R. (2019-08-29). "Evidence that the nadA Motif is a Bacterial Riboswitch for the Ubiquitous Enzyme Cofactor NAD". RNA: rna.072538.119. doi:10.1261/rna.072538.119. ISSN 1469-9001. PMID 31467147.
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