Biology:Ninein
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Short description: Ninein (s.m. Al Ninein) in dialetto Bolognese è il maiale.
 Generic protein structure example |
Ninein is a protein that in humans is encoded by the NIN gene.[1][2][3] Ninein, together with its paralog Ninein-like protein is one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported.[3]
References
- ↑ "Cloning and characterization of a novel human ninein protein that interacts with the glycogen synthase kinase 3beta". Biochim Biophys Acta 1492 (2–3): 513–6. Oct 2000. doi:10.1016/S0167-4781(00)00127-5. PMID 11004522.
- ↑ "Genomic organization and molecular characterization of the human ninein gene". Biochem. Biophys. Res. Commun. 279 (3): 989–95. Feb 2001. doi:10.1006/bbrc.2000.4050. PMID 11162463.
- ↑ 3.0 3.1 "Entrez Gene: NIN ninein (GSK3B interacting protein)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51199.
Further reading
- Nakajima D; Okazaki N; Yamakawa H et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
- Mack GJ; Rees J; Sandblom O et al. (1998). "Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome". Arthritis Rheum. 41 (3): 551–8. doi:10.1002/1529-0131(199803)41:3<551::AID-ART22>3.0.CO;2-X. PMID 9506584.
- Nagase T; Kikuno R; Nakayama M et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
- "CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation". J. Cell Sci. 115 (Pt 9): 1825–35. 2002. doi:10.1242/jcs.115.9.1825. PMID 11956314.
- "Assembly of centrosomal proteins and microtubule organization depends on PCM-1". J. Cell Biol. 159 (2): 255–66. 2002. doi:10.1083/jcb.200204023. PMID 12403812.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Chen CH; Howng SL; Cheng TS et al. (2003). "Molecular characterization of human ninein protein: two distinct subdomains required for centrosomal targeting and regulating signals in cell cycle". Biochem. Biophys. Res. Commun. 308 (4): 975–83. doi:10.1016/S0006-291X(03)01510-9. PMID 12927815.
- "Spectrum of centrosome autoantibodies in childhood varicella and post-varicella acute cerebellar ataxia". BMC Pediatrics 3: 11. 2004. doi:10.1186/1471-2431-3-11. PMID 14503922.
- Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Innocenti M; Zucconi A; Disanza A et al. (2004). "Abi1 is essential for the formation and activation of a WAVE2 signalling complex". Nat. Cell Biol. 6 (4): 319–27. doi:10.1038/ncb1105. PMID 15048123.
- Vizmanos JL; Novo FJ; Román JP et al. (2004). "NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5;14)(q33;q24) and an imatinib-responsive myeloproliferative disorder". Cancer Res. 64 (8): 2673–6. doi:10.1158/0008-5472.CAN-04-0144. PMID 15087377.
- Howng SL; Hsu HC; Cheng TS et al. (2004). "A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors". FEBS Lett. 566 (1–3): 162–8. doi:10.1016/j.febslet.2004.04.024. PMID 15147888.
- "Human ninein is a centrosomal autoantigen recognized by CREST patient sera and plays a regulatory role in microtubule nucleation". Cell Cycle 3 (7): 923–30. 2006. doi:10.4161/cc.3.7.947. PMID 15190203.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- "Microtubule nucleation and anchoring at the centrosome are independent processes linked by ninein function". J. Cell Sci. 118 (Pt 8): 1565–75. 2005. doi:10.1242/jcs.02302. PMID 15784680.
- Cheng TS; Chang LK; Howng SL et al. (2006). "SUMO-1 modification of centrosomal protein hNinein promotes hNinein nuclear localization". Life Sci. 78 (10): 1114–20. doi:10.1016/j.lfs.2005.06.021. PMID 16154161. http://ntur.lib.ntu.edu.tw//handle/246246/196401.
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