Biology:Nuclear prelamin A recognition factor
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Nuclear prelamin A recognition factor, also known as NARF, is a protein which in humans is encoded by the NARF gene.[1][2][3]
Function
Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein–protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing.[1]
Interactions
NARF has been shown to interact with LMNA.[2]
References
- ↑ 1.0 1.1 "Entrez Gene: NARF nuclear prelamin A recognition factor". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26502.
- ↑ 2.0 2.1 "Prenylated prelamin A interacts with Narf, a novel nuclear protein". The Journal of Biological Chemistry 274 (42): 30008–18. Oct 1999. doi:10.1074/jbc.274.42.30008. PMID 10514485.
- ↑ "Eukaryotic Fe-hydrogenases -- old eukaryotic heritage or adaptive acquisitions?". Biochemical Society Transactions 33 (Pt 1): 47–50. Feb 2005. doi:10.1042/BST0330047. PMID 15667261.
Further reading
- "Posttranslational modification of proteins by isoprenoids in mammalian cells". FASEB Journal 4 (15): 3319–28. Dec 1990. doi:10.1096/fasebj.4.15.2123808. PMID 2123808.
- "Prenylated prelamin A interacts with Narf, a novel nuclear protein". The Journal of Biological Chemistry 274 (42): 30008–18. Oct 1999. doi:10.1074/jbc.274.42.30008. PMID 10514485.
- "Eukaryotic Fe-hydrogenases -- old eukaryotic heritage or adaptive acquisitions?". Biochemical Society Transactions 33 (Pt 1): 47–50. Feb 2005. doi:10.1042/BST0330047. PMID 15667261.
- "Towards a proteome-scale map of the human protein–protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. Jan 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF)". The Journal of Biological Chemistry 281 (30): 20749–60. Jul 2006. doi:10.1074/jbc.M602089200. PMID 16714285.
- "RNA-editing-mediated exon evolution". Genome Biology 8 (2): R29. 2007. doi:10.1186/gb-2007-8-2-r29. PMID 17326827.
![]() | Original source: https://en.wikipedia.org/wiki/Nuclear prelamin A recognition factor.
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