Biology:OR3A1
 Generic protein structure example |
Olfactory receptor 3A1 is a protein that in humans is encoded by the OR3A1 gene.[1][2][3]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]
Ligands
OR3A1 is activated by helional and the closely related molecule heliotropylacetone.[4] Other compounds including piperonal, safrole, and vanillin completely failed to activate OR3A1.
Agonists:
- helional[4]
- heliotropylacetone[4]
- lilial[5]
- cyclamen aldehyde[5]
- foliaver (3-(4-methoxyphenyl)-2-methylpropanal)[5]
See also
References
- ↑ "Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity". Genomics 37 (2): 147–60. October 1996. doi:10.1006/geno.1996.0536. PMID 8921386.
- ↑ "Olfactory receptor-encoding genes and pseudogenes are expressed in humans". Gene 169 (2): 247–9. March 1996. doi:10.1016/0378-1119(95)00849-7. PMID 8647456.
- ↑ 3.0 3.1 "Entrez Gene: OR3A1 olfactory receptor, family 3, subfamily A, member 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4994.
- ↑ 4.0 4.1 4.2 "Comparison of odorant specificity of two human olfactory receptors from different phylogenetic classes and evidence for antagonism". Chemical Senses 30 (1): 69–80. January 2005. doi:10.1093/chemse/bji002. PMID 15647465.
- ↑ 5.0 5.1 5.2 "Characterization of an extended receptive ligand repertoire of the human olfactory receptor OR17-40 comprising structurally related compounds". Journal of Neurochemistry 97 (2): 537–44. April 2006. doi:10.1111/j.1471-4159.2006.03771.x. PMID 16539658.
Further reading
- "A new concept of olfactory biosensor based on interdigitated microelectrodes and immobilized yeasts expressing the human receptor OR17-40". European Biophysics Journal 36 (8): 1015–8. November 2007. doi:10.1007/s00249-007-0187-6. PMID 17579849.
- "Visualizing odorant receptor trafficking in living cells down to the single-molecule level". Proceedings of the National Academy of Sciences of the United States of America 103 (39): 14325–30. September 2006. doi:10.1073/pnas.0603942103. PMID 16980412. Bibcode: 2006PNAS..10314325J.
- "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America 101 (8): 2584–9. February 2004. doi:10.1073/pnas.0307882100. PMID 14983052. Bibcode: 2004PNAS..101.2584M.
- "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics 63 (2): 227–45. January 2000. doi:10.1006/geno.1999.6030. PMID 10673334.
- "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire". Human Molecular Genetics 3 (2): 229–35. February 1994. doi:10.1093/hmg/3.2.229. PMID 8004088.
External links
- OR3A1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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