Biology:OSBP2
From HandWiki
 Generic protein structure example |
Oxysterol-binding protein 2 is a protein that in humans is encoded by the OSBP2 gene.[1][2][3][4]
Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternate transcriptional splice variants have been observed but have not been fully characterized.[4]
References
- ↑ "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. Dec 1999. doi:10.1038/990031. PMID 10591208. Bibcode: 1999Natur.402..489D.
- ↑ "Molecular and biochemical characterization of a novel oxysterol-binding protein (OSBP2) highly expressed in retina". J Biol Chem 276 (21): 18570–8. May 2001. doi:10.1074/jbc.M011259200. PMID 11278871.
- ↑ "Oxysterol-binding-protein (OSBP)-related protein 4 binds 25-hydroxycholesterol and interacts with vimentin intermediate filaments". Biochem J 361 (Pt 3): 461–72. Jan 2002. doi:10.1042/0264-6021:3610461. PMID 11802775.
- ↑ 4.0 4.1 "Entrez Gene: OSBP2 oxysterol binding protein 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23762.
Further reading
- "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res. 8 (1): 1–9. 2001. doi:10.1093/dnares/8.1.1. PMID 11258795.
- "The OSBP-related protein family in humans". J. Lipid Res. 42 (8): 1203–13. 2001. doi:10.1016/S0022-2275(20)31570-4. PMID 11483621.
- "A family of 12 human genes containing oxysterol-binding domains". Genomics 78 (3): 185–96. 2002. doi:10.1006/geno.2001.6663. PMID 11735225. https://zenodo.org/record/1229818.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "HLM/OSBP2 is expressed in chronic myeloid leukemia". Int. J. Mol. Med. 12 (4): 663–6. 2004. doi:10.3892/ijmm.12.4.663. PMID 12964051.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Characterization of the sterol-binding domain of oxysterol-binding protein (OSBP)-related protein 4 reveals a novel role in vimentin organization". Exp. Cell Res. 313 (7): 1426–37. 2007. doi:10.1016/j.yexcr.2007.01.018. PMID 17350617.
 |
