Biology:Osteoglycin
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Osteoglycin (also called mimecan), encoded by the OGN gene, is a human protein.[1]
This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor beta. This protein is a small keratan sulfate proteoglycan[2] which contains tandem leucine-rich repeats (LRR). The gene expresses three transcript variants.[1]
The level of expression of this gene has been correlated with enlarged hearts and more specifically left ventricular hypertrophy.[3][4]
References
- ↑ 1.0 1.1 "Entrez Gene: OGN osteoglycin". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4969.
- ↑ Funderburgh JL, Corpuz LM, Roth MR, Funderburgh ML, Tasheva ES, Conrad GW (1997). "Mimecan, the 25-kDa corneal keratan sulfate proteoglycan, is a product of the gene producing osteoglycin.". J Biol Chem 272 (44): 28089–95. doi:10.1074/jbc.272.44.28089. PMID 9346963.
- ↑ "Big hearts 'have genetic problem'". Health. BBC News. 2008-06-06. http://news.bbc.co.uk/2/hi/health/7371213.stm.
- ↑ "Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass". Nat. Genet. 40 (5): 546–52. May 2008. doi:10.1038/ng.134. PMID 18443592.
Further reading
- Kukita A; Bonewald L; Rosen D et al. (1990). "Osteoinductive factor inhibits formation of human osteoclast-like cells". Proc. Natl. Acad. Sci. U.S.A. 87 (8): 3023–6. doi:10.1073/pnas.87.8.3023. PMID 2326263. Bibcode: 1990PNAS...87.3023K.
- Madisen L; Neubauer M; Plowman G et al. (1990). "Molecular cloning of a novel bone-forming compound: osteoinductive factor". DNA Cell Biol. 9 (5): 303–9. doi:10.1089/dna.1990.9.303. PMID 2372374.
- Tasheva ES; Funderburgh ML; McReynolds J et al. (1999). "The bovine mimecan gene. Molecular cloning and characterization of two major RNA transcripts generated by alternative use of two splice acceptor sites in the third exon". J. Biol. Chem. 274 (26): 18693–701. doi:10.1074/jbc.274.26.18693. PMID 10373482.
- "Super-motifs and evolution of tandem leucine-rich repeats within the small proteoglycans--biglycan, decorin, lumican, fibromodulin, PRELP, keratocan, osteoadherin, epiphycan, and osteoglycin". Proteins 38 (2): 210–25. 2000. doi:10.1002/(SICI)1097-0134(20000201)38:2<210::AID-PROT9>3.0.CO;2-1. PMID 10656267.
- Pellegata NS; Dieguez-Lucena JL; Joensuu T et al. (2000). "Mutations in KERA, encoding keratocan, cause cornea plana". Nat. Genet. 25 (1): 91–5. doi:10.1038/75664. PMID 10802664.
- "Assignment of mimecan gene (OGN) to human chromosome band 9q22 by in situ hybridization". Cytogenet. Cell Genet. 88 (3–4): 326–7. 2000. doi:10.1159/000015521. PMID 10828622.
- Hu RM; Han ZG; Song HD et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946. Bibcode: 2000PNAS...97.9543H.
- "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. 2001. doi:10.1101/gr.143000. PMID 11076863.
- Wiemann S; Weil B; Wellenreuther R et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMID 11230166.
- Simpson JC; Wellenreuther R; Poustka A et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- "The UV responsive elements in the human mimecan promoter: a functional characterization". Mol. Vis. 9: 1–9. 2003. PMID 12533723.
- Luijendijk MW; van de Pol TJ; van Duijnhoven G et al. (2004). "Cloning, characterization, and mRNA expression analysis of novel human fetal cochlear cDNAs". Genomics 82 (4): 480–90. doi:10.1016/S0888-7543(03)00150-2. PMID 13679028.
- Humphray SJ; Oliver K; Hunt AR et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053. Bibcode: 2004Natur.429..369H.
- "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. 2005. doi:10.1110/ps.04682504. PMID 15340161.
- Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Wiemann S; Arlt D; Huber W et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
- Hu SM; Li F; Yu HM et al. (2006). "The mimecan gene expressed in human pituitary and regulated by pituitary transcription factor-1 as a marker for diagnosing pituitary tumors". J. Clin. Endocrinol. Metab. 90 (12): 6657–64. doi:10.1210/jc.2005-0322. PMID 16189248.
- Otsuki T; Ota T; Nishikawa T et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Mehrle A; Rosenfelder H; Schupp I et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
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