Biology:Ovomucoid
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Short description: Protein found in egg whites
| Ovomucoid | |||||||
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 The third Kazal domain of the turkey ovomucoid protein (orange) bound to subtilisin Carlsberg, a serine protease.[1] | |||||||
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| Symbol | ? | ||||||
| UniProt | P68390 | ||||||
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| Ovomucoid | |||||||
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| Symbol | ? | ||||||
| UniProt | P01005 | ||||||
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Ovomucoid is a protein found in egg whites. It is a trypsin inhibitor with three protein domains of the Kazal domain family.[2][3] The homologs from chickens (Gallus gallus) and especially turkeys (Meleagris gallopavo) are best characterized. It is not related to the similarly named ovomucin, another egg white protein.
Chicken ovomucoid, also known as Gal d 1, is a known allergen. It is the protein most often causing egg allergy. At least four IgE epitopes have been identified.[4] Three other egg white proteins are also identified as allergenic: ovalbumin (Gal d 2), ovotransferrin (Gal d 3) and lysozyme (Gal d 4).[5]
References
- ↑ "Structure and energetics of protein-protein interactions: the role of conformational heterogeneity in OMTKY3 binding to serine proteases". Journal of Molecular Biology 331 (2): 497–508. August 2003. doi:10.1016/S0022-2836(03)00783-6. PMID 12888355.
- ↑ "Identification of the trypsin inhibitor of egg white with ovomucoid". The Journal of Biological Chemistry 171 (2): 565–81. December 1947. doi:10.1016/S0021-9258(17)41067-2. PMID 20272096.
- ↑ "Structure and function of invertebrate Kazal-type serine proteinase inhibitors". Developmental and Comparative Immunology 34 (4): 377–86. April 2010. doi:10.1016/j.dci.2009.12.004. PMID 19995574.
- ↑ "Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy". Allergy 62 (7): 758–65. July 2007. doi:10.1111/j.1398-9995.2007.01332.x. PMID 17573723.
- ↑ "Current understanding of egg allergy". Pediatr. Clin. North Am. 58 (2): 427–43, xi. 2011. doi:10.1016/j.pcl.2011.02.014. PMID 21453811.
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