Biology:PTRF
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Polymerase I and transcript release factor, also known as Cavin1, Cavin-1 or PTRF, is a protein which in humans is encoded by the PTRF gene.[1][2]
Function
PTRF (Cavin1) has been shown to be crucial for caveola formation and function. [3]
Termination of RNA polymerase I catalyzed transcription is a 2-step process that involves pausing of transcription elongation and release of both the pre-ribosomal RNA and Pol I from the DNA template. The pausing is mediated by TTF1 and PTRF.[4][5]
PTRF is a soluble protein containing putative leucine zipper, nuclear localization signal, and PEST domains.[6]
Interactions
PTRF (Cavin1) forms trimers with Cavin2 and Cavin3 in caveola formation and has been shown to interact with other membrane associating proteins such as EHD2 and caveolins. [7]
PTRF has been shown to interact with ZNF148.[8]
References
- ↑ "Entrez Gene: PTRF polymerase I and transcript release factor". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=284119.
- ↑ "CAVIN1 Symbol Report | HUGO Gene Nomenclature Committee". https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:9688.
- ↑ "PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function" (in en). Cell 132 (1): 113–24. January 2008. doi:10.1016/j.cell.2007.11.042. PMID 18191225.
- ↑ "Identification of a transcript release activity acting on ternary transcription complexes containing murine RNA polymerase I". The EMBO Journal 16 (1): 163–72. January 1997. doi:10.1093/emboj/16.1.163. PMID 9009277.
- ↑ "Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes". The EMBO Journal 17 (10): 2855–64. May 1998. doi:10.1093/emboj/17.10.2855. PMID 9582279.
- ↑ "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes". The Biochemical Journal 383 (Pt 2): 237–48. October 2004. doi:10.1042/BJ20040647. PMID 15242332.
- ↑ "Cavin family proteins and the assembly of caveolae". Journal of Cell Science 128 (7): 1269–78. April 2015. doi:10.1242/jcs.167866. PMID 25829513.
- ↑ "PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters". The Biochemical Journal 347 Pt 1 (Pt 1): 55–9. April 2000. doi:10.1042/0264-6021:3470055. PMID 10727401.
Further reading
- "Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes". The EMBO Journal 17 (10): 2855–64. May 1998. doi:10.1093/emboj/17.10.2855. PMID 9582279.
- "PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters". The Biochemical Journal 347 Pt 1 (Pt 1): 55–9. April 2000. doi:10.1042/0264-6021:3470055. PMID 10727401.
- "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes". The Biochemical Journal 383 (Pt 2): 237–48. October 2004. doi:10.1042/BJ20040647. PMID 15242332.
- "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology 23 (1): 94–101. January 2005. doi:10.1038/nbt1046. PMID 15592455.
- "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Molecular & Cellular Proteomics 4 (9): 1240–50. September 2005. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
- "Association and insulin regulated translocation of hormone-sensitive lipase with PTRF". Biochemical and Biophysical Research Communications 350 (3): 657–61. November 2006. doi:10.1016/j.bbrc.2006.09.094. PMID 17026959.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. November 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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