Biology:PTS-GFL superfamily
The phosphotransferases system (PTS-GFL) superfamily is a superfamily of phosphotransferase enzymes that facilitate the transport of glucose, glucitol (G), fructose (F) and lactose (L). Classification has been established through phylogenic analysis and bioinformatics.[1][2]
The bacterial phosphoenolpyruvate:sugar phosphotransferase system (PTS) transports and phosphorylates its sugar substrates in a single energy-coupled step. This transport process is dependent on several cytoplasmic phosphoryl transfer proteins - Enzyme I (I), HPr, Enzyme IIA (IIA), and Enzyme IIB (IIB)) as well as the integral membrane sugar permease (IIC). The PTS Enzyme II complexes are derived from independently evolving 4 PTS Enzyme II complex superfamilies, that include the (1) Glucose (Glc),(2) Mannose (Man), (3) Ascorbate-Galactitol (Asc-Gat) and (4) Dihydroxyacetone (Dha) superfamilies.
The four families that make up the PTS-GFL superfamily include:
- 4.A.1 – The PTS Glucose-Glucoside (Glc) Family
- 4.A.2 – The PTS Fructose-Mannitol (Fru) Family
- 4.A.3 – The PTS Lactose-N,N'-Diacetylchitobiose-β-glucoside (Lac) Family
- 4.A.4 – The PTS Glucitol (Gut) Family
See also
- Phosphotransferases system
Further reading
- "TCDB - PTS-GFL Superfamily". www.tcdb.org.
- Chang, Abraham B.; Lin, Ron; Keith Studley, W.; Tran, Can V.; Saier, Milton H. (2004-06-01). "Phylogeny as a guide to structure and function of membrane transport proteins". Molecular Membrane Biology 21 (3): 171–181.doi:10.1080/09687680410001720830. ISSN 0968-7688.PMID 15204625.
References
- ↑ Chen, Jonathan S.; Reddy, Vamsee; Chen, Joshua H.; Shlykov, Maksim A.; Zheng, Wei Hao; Cho, Jaehoon; Yen, Ming Ren; Saier, Milton H. (2012-01-01). "Phylogenetic Characterization of Transport Protein Superfamilies: Superiority of SuperfamilyTree Programs over Those Based on Multiple Alignments". Journal of Molecular Microbiology and Biotechnology 21 (3–4): 83–96. doi:10.1159/000334611. ISSN 1464-1801. PMID 22286036.
- ↑ Nguyen, Thai X.; Yen, Ming-Ren; Barabote, Ravi D.; Saier, Milton H. (2006-01-01). "Topological predictions for integral membrane permeases of the phosphoenolpyruvate:sugar phosphotransferase system". Journal of Molecular Microbiology and Biotechnology 11 (6): 345–360. doi:10.1159/000095636. ISSN 1464-1801. PMID 17114898.
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