Biology:Phosducin-like
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Short description: Protein-coding gene in humans
 Generic protein structure example |
Phosducin-like protein is a protein that in humans is encoded by the PDCL gene.[1][2]
Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in the retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins.[2]
References
- ↑ "Cloning and characterization of the rat and human phosducin-like protein genes: structure, expression and chromosomal localization". Biochim Biophys Acta 1444 (3): 346–54. May 1999. doi:10.1016/S0167-4781(99)00006-8. PMID 10095058.
- ↑ 2.0 2.1 "Entrez Gene: PDCL phosducin-like". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5082.
Further reading
- "Phosducin-like protein: an ethanol-responsive potential modulator of guanine nucleotide-binding protein function.". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10831–5. 1993. doi:10.1073/pnas.90.22.10831. PMID 8248177. Bibcode: 1993PNAS...9010831M.
- "Human phosducin-like protein (hPhLP) messenger RNA stability is regulated by cis-acting instability elements present in the 3'-untranslated region.". Biochim. Biophys. Acta 1446 (3): 253–64. 1999. doi:10.1016/S0167-4781(99)00098-6. PMID 10524200.
- "Phosphorylation of phosducin and phosducin-like protein by G protein-coupled receptor kinase 2.". J. Biol. Chem. 275 (38): 29724–30. 2000. doi:10.1074/jbc.M001864200. PMID 10884381.
- "Molecular cloning and characterization of the human phosducin-like protein (hPhLP) promoter.". Biochim. Biophys. Acta 1492 (2–3): 460–4. 2000. doi:10.1016/S0167-4781(00)00137-8. PMID 10899582.
- "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. 2001. doi:10.1101/gr.143000. PMID 11076863.
- "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
- "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. 2001. doi:10.1093/embo-reports/kvd058. PMID 11256614.
- "Regulatory interaction of phosducin-like protein with the cytosolic chaperonin complex.". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 7962–7. 2002. doi:10.1073/pnas.112075699. PMID 12060742. Bibcode: 2002PNAS...99.7962M.
- "Regulation of phosducin-like protein by casein kinase 2 and N-terminal splicing.". J. Biol. Chem. 278 (7): 4474–81. 2003. doi:10.1074/jbc.M206347200. PMID 12466282.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. 2004. doi:10.1101/gr.2576704. PMID 15489336.
- "Identification of phosphorylation sites on phosducin-like protein by QTOF mass spectrometry.". J Biomol Tech 15 (4): 257–64. 2005. PMID 15585822.
- "Phosducin-like protein regulates G-protein betagamma folding by interaction with tailless complex polypeptide-1alpha: dephosphorylation or splicing of PhLP turns the switch toward regulation of Gbetagamma folding.". J. Biol. Chem. 280 (20): 20042–50. 2005. doi:10.1074/jbc.M409233200. PMID 15745879.
- "Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly.". EMBO J. 24 (11): 1965–75. 2005. doi:10.1038/sj.emboj.7600673. PMID 15889144.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. 2006. doi:10.1093/nar/gkj139. PMID 16381901.
- "Mechanism of assembly of G protein betagamma subunits by protein kinase CK2-phosphorylated phosducin-like protein and the cytosolic chaperonin complex.". J. Biol. Chem. 281 (31): 22261–74. 2006. doi:10.1074/jbc.M601590200. PMID 16717095.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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