Biology:Protein THEMIS
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Protein THEMIS is a protein that in humans is encoded by the THEMIS gene.[1][2][3]
Function
This protein plays a regulatory role in both positive and negative T cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells.[4]
The name
THEMIS is an acronym for thymocyte-expressed-molecule. Themis is also the name of a Titan in Greek mythology who weighed the fates of humans, an apt choice since the protein is important in deciding the fate of the T cell during development.[5]
References
- ↑ "Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling". Nat. Immunol. 10 (8): 848–56. August 2009. doi:10.1038/ni.1766. PMID 19597499.
- ↑ "Themis, a T cell-specific protein important for late thymocyte development". Nat. Immunol. 10 (8): 840–7. August 2009. doi:10.1038/ni.1768. PMID 19597498.
- ↑ "Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection". Nat. Immunol. 10 (8): 831–9. August 2009. doi:10.1038/ni.1769. PMID 19597497.
- ↑ "Entrez Gene: thymocyte selection associated". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=387357.
- ↑ Zielinska E (2009-11-01). "Six degrees of science". The Scientist. http://www.the-scientist.com/2009/11/1/18/1/.
Further reading
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932.
- "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. 2001. doi:10.1038/88107. PMID 11329013.
- Allen PM (2009). "Themis imposes new law and order on positive selection.". Nat. Immunol. 10 (8): 805–6. doi:10.1038/ni0809-805. PMID 19621038.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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