Biology:Psychosocial Genomics

From HandWiki

Psychosocial Genomics (PG) is a field of research first proposed by Ernest L. Rossi in 2002.[1] PG examines the modulation of gene expression in response to psychological, social and cultural experiences.[2][3] Independent research shows that the experience of novelty,[4] environmental enrichment[5][6] and exercise[7][8][9] facilitates activity and experience dependent gene expression and brain plasticity as well as stem cell healing processes.[10][11]

Ernest L. Rossi describes the new science of Psychosocial Genomics:

"I call this new perspective on the role of genes as active players in psychological experience psychosocial genomics. Psychosocial genomics focuses on the how the highly personal and subjective states of human consciousness can modulate gene expression in the brain and body for illness or health."[12]

This is a top-down approach – from mind to body – that modulates the role of gene expression and brain plasticity in the development of human consciousness which can be perceived as the completion, or dynamic complement, of the bottom-up approach – direct sensorial and biological responses – as proposed by the ENCODE consortium.[13][14]

Psychosocial Genomics utilizes in its research various kinds of methods and approaches derived from genomics, neuroscience and culturomics,[15][16] including DNA microarrays, and computational analysis with the GSEA database.[17]

References

  1. ↑ Rossi, E. L. (2002). The Psychobiology of Gene Expression: Neuroscience and Neurogenesis in Therapeutic Hypnosis and the Healing Arts. New York: W. W. Norton Professional Books.
  2. ↑ Garland, E., & Howard, M.O. (2009) Neuroplasticity, psychosocial genomics, and the biopsychosocial paradigm of the 21st century. Health and Social Work, 34(3): 191-199
  3. ↑ Hill, R. (2014). Psychosocial Genomics: A New Vision of the Psychotherapeutic Arts. International Journal of Psychosocial Genonics, 1(1): 38-48.
  4. ↑ Eriksson, P., Perfilieva, E., Björk-Ericksson, T., Alborn, A.-M., Nordborg, C., Peterson, D., & Gage, F. (1998). Neurogenesis in the adult human hippocampus. Nature Medicine, (4), 1313–1317.
  5. ↑ Clelland, C., Choi, M., Romberg, C., Clemenson, G., Fragniere, A., Tyers, P., … Bussey, F. (2009). A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science, (325), 210–213 .
  6. ↑ Kempermann, G., Kuhn,, G., & Gage, F. (1997). More hippocampal neurons in adult mice living in an enriched environment. Nature, (386), 493–495.
  7. ↑ Loebrich, S., & Nedivi, E. (2009). The Function of Activity-Regulated Genes in the Nervous System. Physiology Review, (89), 1079–1103.
  8. ↑ Van Praag, H., Schinder, A., Christie, B., Toni, N., Palmer, T., & Gage, F. (2002). Functional Neurogenesis in the Adult Hippocampus. Nature, (415), 1030–1034.
  9. ↑ Van Praag, H., Kempermann, G., & Gage, F. (1999). Running increases cell proliferation and neurogenesis in adult mouse dentate gyrus. Nature Neuroscience, (2), 266–270.
  10. ↑ Rossi, E. L., & Rossi, K. L. (2013). Creating New Consciousness in Everyday Life - The Psycho-Social Genomics of Self Creation. Los Osos, CA: Palisades Gateway Publishing.
  11. ↑ Rossi, E. L. (2002). The Psychobiology of Gene Expression: Neuroscience and Neurogenesis in Therapeutic Hypnosis and the Healing Arts. New York: W. W. Norton Professional Books.
  12. ↑ Rossi, E. L. (2007). Art, Beauty and Truth: The Psychosocial Genomics of Consciousness, Dreams and Brain Growth in Psychotherapy and Mind-Body Healing. In The Breakout Heuristic - The New Neuroscience of Mirror Neurons, Consciousness and Creativity in Human Relationships (pp. 369–381). Phoenix, AZ: The Milton H. Erickson Foundation Press, p. 370
  13. ↑ ENCODE Project Consotium. (2004) The ENCODE (ENCyclopedia Of DNA Elements) Project. Science, 306(5696): 636-640.
  14. ↑ Rossi, E. L., & Rossi, K. L. (2013). Creating New Consciousness in Everyday Life - The Psycho-Social Genomics of Self Creation. Los Osos, CA: Palisades Gateway Publishing.
  15. ↑ Rossi, E. L., Mortimer, J., & Rossi, K. L. (2012). Therapeutic Hypnosis, Psychotherapy and the Digital Humanities: The Culturomics and Narratives of Hypnosis, 1800-2008. American Journal of Clinical Hypnosis, 3(54), 153–169.
  16. ↑ Rossi, E. L., & Rossi, K. L. (2013). Creating New Consciousness in Everyday Life - The Psycho-Social Genomics of Self Creation. Los Osos, CA: Palisades Gateway Publishing.
  17. ↑ Atkinson, D., Iannotti, S., Cozzolino, M., Castiglione, S., Cicatelli, A., Vyas, B., Mortimer, J., Hill, R., Chovanec, E., Chiamberlando, A., Cuadros, J., Virot, C., Kerouac, M., Kallfass, T., Krippner, S., Frederick, C., Gregory, B., Shaffran, M., Bullock, M., Soleimany, E., Rossi, A. C., Rossi, K., & Rossi, E. (2010) A new bioinformatics paradigm for the theory, research, and practice of therapeutic hypnosis. American Journal of Clinical Hypnosis, 53(1): 27-46.




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