Biology:Pyrrole–imidazole polyamides
From HandWiki
Short description: Chemical compound
Pyrrole–imidazole polyamides (PIPs) are a class of polyamides have the ability to bind to minor grooves found in the DNA helix.[1][2] Scientists are experimenting with it as a drug-delivery mode that can switch genes on and off, as well as epigenetic modification in gene therapy.[3]
References
- ↑ Kawamoto, Yusuke; Bando, Toshikazu; Sugiyama, Hiroshi (May 2018). "Sequence-specific DNA binding Pyrrole–imidazole polyamides and their applications". Bioorganic & Medicinal Chemistry 26 (8): 1393–1411. doi:10.1016/j.bmc.2018.01.026. PMID 29439914.
- ↑ Wu, Chunlei; Wang, Wei; Fang, Lijing; Su, Wu (July 2018). "Programmable pyrrole-imidazole polyamides: A potent tool for DNA targeting". Chinese Chemical Letters 29 (7): 1105–1112. doi:10.1016/j.cclet.2018.05.025.
- ↑ "Advancing gene therapies: PIP pip hurray!". https://phys.org/news/2020-02-advancing-gene-therapies-pip-hurray.html.
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