Biology:Quantitative pharmacology
Quantitative Pharmacology (QP), or Quantitative Systems Pharmacology[1] (QSP), is an organized approach integrating individuals from different disciplines in a combined effort to develop quantitative models in order to solve specific, complex, and multivariate problems in drug development. QP translates the relationship(s) between disease, drug action, and individual variability into improved patient outcomes by leveraging improved teamwork and collaboration to enable quantitative decision-making processes from early discovery to late-stage development. QP encourages more transparent and objective study designs, as well as more data-driven risk-taking to optimize timelines, analyses, and decision-making, resulting in greater efficiency in the drug development process.
References
- ↑ "Quantitative Systems Pharmacology". Cambridge Healthtech Institute. http://www.discoveryontarget.com/quantitative-pharmacology/.
- Atkinson, AJ Jr; Lalonde, RL (Jul 2007). "Introduction of quantitative methods in pharmacology and clinical pharmacology: a historical overview". Clin Pharmacol Ther 82 (1): 3–6. doi:10.1038/sj.clpt.6100248. PMID 17571065.
- Barrett, JS (2008). "The role of quantitative pharmacology in an academic translational research environment". AAPS J. 10 (1): 9–14. doi:10.1208/s12248-007-9002-7. PMID 18446501.
- Barrett, JS; Shi, J; Xie, HT; Huang, XH; Fossler, MJ; Sun, RY (Jul 2008). "Globalization of quantitative pharmacology: first international symposium of quantitative pharmacology in drug development and regulation". J Clin Pharmacol 48 (7): 787–92. doi:10.1177/0091270008319331. PMID 18490494.
- Holford, N; Karlsson, MO (Jul 2007). "Time for quantitative clinical pharmacology: a proposal for a pharmacometrics curriculum". Clin Pharmacol Ther 82 (1): 103–5. doi:10.1038/sj.clpt.6100231. PMID 17495873.
- Krishna, R (Sep 2006). "Quantitative clinical pharmacology: Making paradigm shifts a reality". J Clin Pharmacol 46 (9): 966–7. doi:10.1177/0091270006292978. PMID 16920890.
- Putnam, WS; Li, J; Haggstrom, J; Ng, C; Kadkhodayan-Fischer, S; Cheu, M; Deniz, Y; Lowman, H et al. (Jun 2008). "Use of quantitative pharmacology in the development of HAE1, a high-affinity anti-IgE monoclonal antibody". AAPS J. 10 (2): 425–30. doi:10.1208/s12248-008-9045-4. PMID 18686041.
- Zhang, L; Pfister, M; Meibohm, B (2008). "Concepts and Challenges in Quantitative Pharmacology and Model-Based Drug Development". AAPS J. 10 (4): 552–9. doi:10.1208/s12248-008-9062-3. PMID 19003542.
- Zhang, L; Sinha, V; Forgue, ST; Callies, S; Ni, L; Peck, R; Allerheiligen, SR (Jun 2006). "Model-based drug development: the road to quantitative pharmacology". J Pharmacokinet Pharmacodyn 33 (3): 369–93. doi:10.1007/s10928-006-9010-8. PMID 16770528.
 |  |
