Biology:RBPMS
 Generic protein structure example |
RNA-binding protein with multiple splicing is a protein that in humans is encoded by the RBPMS gene.[1][2]
Function
This gene encodes a member of the RRM family of RNA-binding proteins. The RRM domain is between 80-100 amino acids in length and family members contain one to four copies of the domain. The RRM domain consists of two short stretches of conserved sequence called RNP1 and RNP2, as well as a few highly conserved hydrophobic residues. The protein encoded by this gene has a single, putative RRM domain in its N-terminus. Alternative splicing results in multiple transcript variants encoding different isoforms.[2]
It is uniquely expressed in retinal ganglion cells in the mammalian retina,[3] for reasons unknown.
Interactions
RBPMS has been shown to interact with SMUG1.[4]
References
- ↑ "A unique human gene that spans over 230 kb in the human chromosome 8p11-12 and codes multiple family proteins sharing RNA-binding motifs". Proc. Natl. Acad. Sci. U.S.A. 93 (20): 10913–7. Nov 1996. doi:10.1073/pnas.93.20.10913. PMID 8855282.
- ↑ 2.0 2.1 "Entrez Gene: RBPMS RNA binding protein with multiple splicing". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11030.
- ↑ "The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina". J. Comp. Neurol. 522 (6): 1411–43. Mar 2014. doi:10.1002/cne.23521. PMID 24318667.
- ↑ "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514.
Further reading
- "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514.
- "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. 2004. doi:10.1038/nbt971. PMID 15146197.
- "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. 2004. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
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