Biology:RC3H1

Generic protein structure example

Ring finger and CCCH-type domains 1, also known as Roquin-1, is a protein that in humans is encoded by the RC3H1 gene.

Function

The consensus primary sequence and secondary structure for the Roquin-1 (RC3H1) binding site (also called constitutive decay element (CDE)).

This gene encodes a protein containing RING-type and C3H1-type zinc finger motifs. The encoded protein recognizes and binds to a constitutive decay element (CDE) in the 3' UTR of mRNAs, leading to mRNA deadenylation and degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].

Further reading

• "Loss of Roquin induces early death and immune deregulation but not autoimmunity". The Journal of Experimental Medicine 208 (9): 1749–56. August 2011. doi:10.1084/jem.20110578. PMID 21844204. 
• "Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs". Cell 153 (4): 869–81. May 2013. doi:10.1016/j.cell.2013.04.016. PMID 23663784. 
• "Molecular control of Tfh-cell differentiation by Roquin family proteins". Immunological Reviews 253 (1): 273–89. May 2013. doi:10.1111/imr.12056. PMID 23550652. 
• "Breakdown in repression of IFN-γ mRNA leads to accumulation of self-reactive effector CD8+ T cells". Journal of Immunology 189 (2): 701–10. July 2012. doi:10.4049/jimmunol.1102432. PMID 22685317. 
• "The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs". The FEBS Journal 277 (9): 2109–27. May 2010. doi:10.1111/j.1742-4658.2010.07628.x. PMID 20412057. 
• "Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA". Nature 450 (7167): 299–303. November 2007. doi:10.1038/nature06253. PMID 18172933. Bibcode: 2007Natur.450..299D. 
• "Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation". Immunity 38 (4): 669–80. April 2013. doi:10.1016/j.immuni.2013.01.011. PMID 23583642. 
• "A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity". Nature 435 (7041): 452–8. May 2005. doi:10.1038/nature03555. PMID 15917799. Bibcode: 2005Natur.435..452V. 
• "Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS". Immunity 30 (2): 228–41. February 2009. doi:10.1016/j.immuni.2008.12.015. PMID 19217324. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.