Biology:RCC2
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Protein RCC2 also known as telophase disk protein of 60 kDa (TD-60) or RCC1-like protein TD-60 is a protein that in humans is encoded by the RCC2 gene.[1][2][3]
Function
RCC2 has structural similarity to RCC1, and has been shown to have weak guanine nucleotide exchange factor (GEF) activity on the small GTPase Rac.[2] TD-60 has also been shown to interact with the Chromosomal Passenger Complex (CPC), and to activate the catalytic component of the CPC, Aurora B, in the presence of microtubules.[4][5]
References
- ↑ "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res 7 (2): 143–50. Sep 2000. doi:10.1093/dnares/7.2.143. PMID 10819331.
- ↑ 2.0 2.1 "The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression". Dev Cell 5 (2): 295–307. Aug 2003. doi:10.1016/S1534-5807(03)00205-3. PMID 12919680.
- ↑ "Entrez Gene: RCC2 regulator of chromosome condensation 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55920.
- ↑ "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". J. Cell Biol. 166 (2): 179–91. July 2004. doi:10.1083/jcb.200404001. PMID 15249581.
- ↑ "Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation". Science 319 (5862): 469–72. January 2008. doi:10.1126/science.1148980. PMID 18218899. Bibcode: 2008Sci...319..469R.
Further reading
- "Telophase disc: a new mammalian mitotic organelle that bisects telophase cells with a possible function in cytokinesis.". J. Cell Sci. 99 (3): 523–34. 1991. PMID 1939370.
- "Delay of HeLa cell cleavage into interphase using dihydrocytochalasin B: retention of a postmitotic spindle and telophase disc correlates with synchronous cleavage recovery.". J. Cell Biol. 131 (1): 191–205. 1995. doi:10.1083/jcb.131.1.191. PMID 7559776.
- "Colocalization of TD-60 and INCENP throughout G2 and mitosis: evidence for their possible interaction in signalling cytokinesis.". Chromosoma 107 (6–7): 461–70. 1999. doi:10.1007/s004120050330. PMID 9914378.
- "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell 13 (11): 4100–9. 2003. doi:10.1091/mbc.E02-05-0271. PMID 12429849.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". J. Cell Biol. 166 (2): 179–91. 2004. doi:10.1083/jcb.200404001. PMID 15249581.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Rosasco-Nitcher, Sara; Lan W; Khorasanizadeh S; Stukenberg PT. (January 2008). "Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation". Science 319 (5862): 469–472. doi:10.1126/science.1148980. PMID 18218899. Bibcode: 2008Sci...319..469R.
External links
- Overview of all the structural information available in the PDB for UniProt: Q9P258 (Protein RCC2) at the PDBe-KB.
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