Biology:RGS1

Generic protein structure example

Regulator of G-protein signaling 1 is a protein that in humans is encoded by the RGS1 gene.

This gene encodes a member of the regulator of G-protein signaling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.

Further reading

• "Isolation and characterization of a novel B cell activation gene.". J. Immunol. 150 (9): 3895–904. 1993. PMID 8473738. 
• "Comparison of mRNA expression of two regulators of G-protein signaling, RGS1/BL34/1R20 and RGS2/G0S8, in cultured human blood mononuclear cells.". DNA Cell Biol. 16 (5): 589–98. 1997. doi:10.1089/dna.1997.16.589. PMID 9174164. 
• "Regulation of chemotactic and proadhesive responses to chemoattractant receptors by RGS (regulator of G-protein signaling) family members.". J. Biol. Chem. 273 (43): 28040–8. 1998. doi:10.1074/jbc.273.43.28040. PMID 9774420. 
• "RGS1 is expressed in monocytes and acts as a GTPase-activating protein for G-protein-coupled chemoattractant receptors.". J. Biol. Chem. 274 (38): 26860–8. 1999. doi:10.1074/jbc.274.38.26860. PMID 10480894. 
• "Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity.". J. Biol. Chem. 275 (25): 18962–8. 2000. doi:10.1074/jbc.M001128200. PMID 10747990. 
• "MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 3999–4004. 2000. doi:10.1073/pnas.97.8.3999. PMID 10760272. Bibcode: 2000PNAS...97.3999Z. 
• "GIPC and GAIP Form a Complex with TrkA: A Putative Link between G Protein and Receptor Tyrosine Kinase Pathways". Mol. Biol. Cell 12 (3): 615–27. 2001. doi:10.1091/mbc.12.3.615. PMID 11251075. 
• "Differential capacities of the RGS1, RGS16 and RGS-GAIP regulators of G protein signaling to enhance alpha2A-adrenoreceptor agonist-stimulated GTPase activity of G(o1)alpha". J. Neurochem. 78 (4): 797–806. 2001. doi:10.1046/j.1471-4159.2001.00479.x. PMID 11520900. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "CXC chemokine ligand 12-induced focal adhesion kinase activation and segregation into membrane domains is modulated by regulator of G protein signaling 1 in pro-B cells". J. Immunol. 174 (5): 2582–90. 2005. doi:10.4049/jimmunol.174.5.2582. PMID 15728464. 
• "RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization". J. Leukoc. Biol. 79 (6): 1357–68. 2006. doi:10.1189/jlb.1105693. PMID 16565322. 
• "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. 2006. doi:10.1038/nature04727. PMID 16710414. Bibcode: 2006Natur.441..315G.