Biology:RGS18
Generic protein structure example |
Regulator of G-protein signaling 18 is a protein that in humans is encoded by the RGS18 gene.[1][2]
Function
This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[2]
Interactions
RGS18 has been shown to interact with GNAI3.[3][4]
References
- ↑ "Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells". The Journal of Biological Chemistry 276 (2): 915–23. Jan 2001. doi:10.1074/jbc.M005947200. PMID 11042171.
- ↑ 2.0 2.1 "Entrez Gene: RGS18 regulator of G-protein signalling 18". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64407.
- ↑ "RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes". The Biochemical Journal 359 (Pt 1): 109–18. Oct 2001. doi:10.1042/bj3590109. PMID 11563974.
- ↑ "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cellular Signalling 14 (7): 595–606. Jul 2002. doi:10.1016/S0898-6568(02)00012-8. PMID 11955952.
Further reading
- "A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes". Blood 97 (10): 3051–60. May 2001. doi:10.1182/blood.V97.10.3051. PMID 11342430.
- "RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes". The Biochemical Journal 359 (Pt 1): 109–18. Oct 2001. doi:10.1042/bj3590109. PMID 11563974.
- "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics 79 (2): 177–85. Feb 2002. doi:10.1006/geno.2002.6693. PMID 11829488.
- "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cellular Signalling 14 (7): 595–606. Jul 2002. doi:10.1016/S0898-6568(02)00012-8. PMID 11955952.
- "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology 21 (5): 566–9. May 2003. doi:10.1038/nbt810. PMID 12665801.
- "Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system". Brain Research. Molecular Brain Research 122 (1): 24–34. Mar 2004. doi:10.1016/j.molbrainres.2003.11.014. PMID 14992813.
- "Assignment of UCK2, ATF3 and RGS18 from human chromosome 1 to porcine chromosomes 4, 9 and 10 with somatic and radiation hybrid panels". Cytogenetic and Genome Research 112 (3–4): 341F. 2006. doi:10.1159/000089896. PMID 16484797.