Biology:RGS18

Generic protein structure example

Regulator of G-protein signaling 18 is a protein that in humans is encoded by the RGS18 gene.

Function

This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Interactions

RGS18 has been shown to interact with GNAI3.

Further reading

• "A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes". Blood 97 (10): 3051–60. May 2001. doi:10.1182/blood.V97.10.3051. PMID 11342430. 
• "RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes". The Biochemical Journal 359 (Pt 1): 109–18. Oct 2001. doi:10.1042/bj3590109. PMID 11563974. 
• "Evolution of the regulators of G-protein signaling multigene family in mouse and human". Genomics 79 (2): 177–85. Feb 2002. doi:10.1006/geno.2002.6693. PMID 11829488. 
• "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cellular Signalling 14 (7): 595–606. Jul 2002. doi:10.1016/S0898-6568(02)00012-8. PMID 11955952. 
• "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology 21 (5): 566–9. May 2003. doi:10.1038/nbt810. PMID 12665801. 
• "Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system". Brain Research. Molecular Brain Research 122 (1): 24–34. Mar 2004. doi:10.1016/j.molbrainres.2003.11.014. PMID 14992813. 
• "Assignment of UCK2, ATF3 and RGS18 from human chromosome 1 to porcine chromosomes 4, 9 and 10 with somatic and radiation hybrid panels". Cytogenetic and Genome Research 112 (3–4): 341F. 2006. doi:10.1159/000089896. PMID 16484797.