Biology:RIF1
From HandWiki
 Generic protein structure example |
Telomere-associated protein RIF1 is a protein that in humans is encoded by the RIF1 gene.[1][2][3]
RIF1 and RIF2 cap the chromosome ends (telomeres) in yeast.[4] In higher eukaryotes, Rif1 is involved in DNA damage response, organisation of chromatin architecture and the regulation of replication timing. RIF1 has been shown to bind to RNA in the nucleus.[5]
References
- ↑ "Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint". Genes & Development 18 (17): 2108–19. September 2004. doi:10.1101/gad.1216004. PMID 15342490.
- ↑ "Identification and characterisation of mRif1: a mouse telomere-associated protein highly expressed in germ cells and embryo-derived pluripotent stem cells". Developmental Dynamics 229 (4): 733–44. April 2004. doi:10.1002/dvdy.10471. PMID 15042697.
- ↑ "Entrez Gene: RIF1 RAP1 interacting factor homolog (yeast)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55183.
- ↑ "Anticheckpoint pathways at telomeres in yeast". Nature Structural & Molecular Biology 19 (3): 307–13. 2012. doi:10.1038/nsmb.2225. PMID 22343724.
- ↑ "Serial interactome capture of the human cell nucleus". Nature Communications 7: 11212. 2016-01-01. doi:10.1038/ncomms11212. PMID 27040163.
Further reading
- "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry 236 (1): 107–13. April 1996. doi:10.1006/abio.1996.0138. PMID 8619474.
- "Large-scale concatenation cDNA sequencing". Genome Research 7 (4): 353–8. April 1997. doi:10.1101/gr.7.4.353. PMID 9110174.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. August 2004. doi:10.1073/pnas.0404720101. PMID 15302935.
- "Human Rif1 protein binds aberrant telomeres and aligns along anaphase midzone microtubules". The Journal of Cell Biology 167 (5): 819–30. December 2004. doi:10.1083/jcb.200408181. PMID 15583028.
- "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology 24 (10): 1285–92. October 2006. doi:10.1038/nbt1240. PMID 16964243.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. November 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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