Biology:RIT2
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Short description: Protein-coding gene in humans
 Generic protein structure example |
GTP-binding protein Rit2 is a protein that in humans is encoded by the RIT2 gene.[1][2][3]
RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999).[supplied by OMIM][3]
RIT2 has been associated with Parkinson's disease in two large genetic studies.[4][5] An gene expression study of postmortem brain has suggested RIT2 interacts with interferon-γ signalling.[6]
Interactions
RIT2 has been shown to interact with POU4F1.[7]
References
- ↑ "Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins". The Journal of Neuroscience 16 (21): 6784–94. November 1996. doi:10.1523/JNEUROSCI.16-21-06784.1996. PMID 8824319.
- ↑ "RIC, a calmodulin-binding Ras-like GTPase". The EMBO Journal 15 (21): 5839–48. November 1996. doi:10.1002/j.1460-2075.1996.tb00971.x. PMID 8918462.
- ↑ 3.0 3.1 "Entrez Gene: RIT2 Ras-like without CAAX 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6014.
- ↑ "Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2". Annals of Neurology 71 (3): 370–84. March 2012. doi:10.1002/ana.22687. PMID 22451204.
- ↑ "Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease". Nature Genetics 46 (9): 989–93. September 2014. doi:10.1038/ng.3043. PMID 25064009. PMC 4146673. http://pubman.mpdl.mpg.de/pubman/item/escidoc:2129586/component/escidoc:2129585/Nalls.pdf.
- ↑ "Differential Co-Expression between α-Synuclein and IFN-γ Signaling Genes across Development and in Parkinson's Disease". PLOS ONE 9 (12): e115029. 2014. doi:10.1371/journal.pone.0115029. PMID 25493648. Bibcode: 2014PLoSO...9k5029L.
- ↑ "Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor". Oncogene 22 (35): 5408–14. August 2003. doi:10.1038/sj.onc.1206635. PMID 12934100.
Further reading
- "Biochemical characterization of the Ras-related GTPases Rit and Rin". Archives of Biochemistry and Biophysics 371 (2): 207–19. November 1999. doi:10.1006/abbi.1999.1448. PMID 10545207.
- "The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation". Biochemical and Biophysical Research Communications 295 (3): 651–6. July 2002. doi:10.1016/S0006-291X(02)00731-3. PMID 12099688.
- "Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor". Oncogene 22 (35): 5408–14. August 2003. doi:10.1038/sj.onc.1206635. PMID 12934100.
- "Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin". BMC Neuroscience 6: 53. August 2005. doi:10.1186/1471-2202-6-53. PMID 16122393.
- "Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation". The Journal of Biological Chemistry 280 (45): 37599–609. November 2005. doi:10.1074/jbc.M507364200. PMID 16157584.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
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