Biology:RRBP1
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Ribosome-binding protein 1, also referred to as p180, is a protein that in humans is encoded by the RRBP1 gene.[1][2]
RRBP1 is a membrane-bound protein found in the endoplasmic reticulum (ER). It was originally identified as the ribosome receptor for the ER,[3] however several groups later demonstrated that this activity did not co-fractionate with RRBP1 [4] [5] but rather with Sec61 (i.e. the translocon).[6][7] RRBP1 can enhance the association of certain mRNAs to the endoplasmic reticulum in a manner that does not require ribosome activity, likely by directly associating the mRNA's phosphate backbone.[8] In addition, RRBP1 may promote the association of polysomes with the translocon [9][10] and play a role in ER morphology.[11] RRBP1 may also bind to microtubules.[12] Although the p180 isoform is the most abundant, it may exist in different forms due to removal of tandem repeats by partial intraexonic splicing. RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome.[2]
References
- ↑ "Identification, characterization, and chromosomal localization of the human homolog (hES) of ES/130". Genomics 35 (3): 628–31. Dec 1996. doi:10.1006/geno.1996.0413. PMID 8812507.
- ↑ 2.0 2.1 "Entrez Gene: RRBP1 ribosome binding protein 1 homolog 180kDa (dog)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6238.
- ↑ Savitz, Adam J.; Meyer, David I. (1990). "Identification of a ribosome receptor in the rough endoplasmic reticulum". Nature 346 (6284): 540–544. doi:10.1038/346540a0. ISSN 0028-0836. PMID 2165568. Bibcode: 1990Natur.346..540S.
- ↑ Nunnari, Jodi M.; Zimmerman, Deborah L.; Ogg, Stephen C.; Walter, Peter (1991). "Characterization of the rough endoplasmic reticulum ribosome-binding activity". Nature 352 (6336): 638–640. doi:10.1038/352638a0. ISSN 0028-0836. PMID 1650916. Bibcode: 1991Natur.352..638N.
- ↑ Collins, PG; Gilmore, R L (1991). "Ribosome binding to the endoplasmic reticulum: a 180-kD protein identified by crosslinking to membrane-bound ribosomes is not required for ribosome binding activity". Journal of Cell Biology 114 (4): 639–49. doi:10.1083/jcb.114.4.639. PMID 1869584.
- ↑ Görlich, Dirk; Prehn, Siegfried; Hartmann, Enno; Kalies, Kai-Uwe; Rapoport, Tom A. (1992). "A mammalian homolog of SEC61p and SECYp is associated with ribosomes and nascent polypeptides during translocation". Cell 71 (3): 489–503. doi:10.1016/0092-8674(92)90517-G. ISSN 0092-8674. PMID 1423609.
- ↑ Gorlich, D (1993). "Protein translocation into proteoliposomes reconstituted from purified components of the endoplasmic reticulum membrane". Cell 75 (4): 615–630. doi:10.1016/0092-8674(93)90483-7. ISSN 0092-8674. PMID 8242738. http://edoc.mdc-berlin.de/1126/1/1126oa.pdf.
- ↑ Cui, Xianying A.; Zhang, Hui; Palazzo, Alexander F. (2012). "p180 Promotes the Ribosome-Independent Localization of a Subset of mRNA to the Endoplasmic Reticulum". PLOS Biology 10 (5): e1001336. doi:10.1371/journal.pbio.1001336. ISSN 1545-7885. PMID 22679391.
- ↑ Dejgaard, Kurt; Theberge, Jean-Francois; Heath-Engel, Hannah; Chevet, Eric; Tremblay, Michel L.; Thomas, David Y. (2010). "Organization of the Sec61 Translocon, Studied by High Resolution Native Electrophoresis". Journal of Proteome Research 9 (4): 1763–1771. doi:10.1021/pr900900x. ISSN 1535-3893. PMID 20112977.
- ↑ Ueno, T.; Kaneko, K.; Sata, T.; Hattori, S.; Ogawa-Goto, K. (2011). "Regulation of polysome assembly on the endoplasmic reticulum by a coiled-coil protein, p180". Nucleic Acids Research 40 (7): 3006–3017. doi:10.1093/nar/gkr1197. ISSN 0305-1048. PMID 22156060.
- ↑ Shibata, Yoko; Shemesh, Tom; Prinz, William A.; Palazzo, Alexander F.; Kozlov, Michael M.; Rapoport, Tom A. (2010). "Mechanisms Determining the Morphology of the Peripheral ER". Cell 143 (5): 774–788. doi:10.1016/j.cell.2010.11.007. ISSN 0092-8674. PMID 21111237.
- ↑ "p180 Is Involved in the Interaction between the Endoplasmic Reticulum and Microtubules through a Novel Microtubule-binding and Bundling Domain". Mol. Biol. Cell 18 (10): 3741–51. 2007. doi:10.1091/mbc.E06-12-1125. PMID 17634287.
Further reading
- "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. 2003. doi:10.1093/dnares/9.3.99. PMID 12168954.
- "Identification of a ribosome receptor in the rough endoplasmic reticulum". Nature 346 (6284): 540–4. 1990. doi:10.1038/346540a0. PMID 2165568. Bibcode: 1990Natur.346..540S.
- "Identification of multiple forms of 180-kDa ribosome receptor in human cells". DNA Cell Biol. 17 (5): 449–60. 1998. doi:10.1089/dna.1998.17.449. PMID 9628588.
- "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. 2000. doi:10.1093/dnares/7.1.65. PMID 10718198.
- "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. 2002. doi:10.1038/414865a. PMID 11780052. Bibcode: 2001Natur.414..865D.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The ribosome receptor, p180, interacts with kinesin heavy chain, KIF5B". Biochem. Biophys. Res. Commun. 319 (3): 987–92. 2004. doi:10.1016/j.bbrc.2004.05.069. PMID 15184079.
- "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. 2006. doi:10.1038/nbt1240. PMID 16964243.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
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