Biology:Renin receptor
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
The renin receptor also known as ATPase H(+)-transporting lysosomal accessory protein 2, or the prorenin receptor, is a protein that in humans is encoded by the ATP6AP2 gene.[1][2][3]
Function
The renin receptor binds renin and prorenin. Binding of renin to this receptor induces the conversion of angiotensinogen to angiotensin I.[4]
This protein is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. This protein has been found associated with the transmembrane sector of the V-type ATPases.[3]
References
- ↑ "Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules". J Biol Chem 273 (18): 10939–47. Jun 1998. doi:10.1074/jbc.273.18.10939. PMID 9556572.
- ↑ "Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4)". Mol Vis 7: 234–9. Oct 2001. PMID 11590366.
- ↑ 3.0 3.1 "Entrez Gene: ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10159.
- ↑ "Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin". J. Clin. Invest. 109 (11): 1417–27. June 2002. doi:10.1172/JCI14276. PMID 12045255.
Further reading
- "Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats". J. Am. Soc. Nephrol. 18 (6): 1789–95. 2007. doi:10.1681/ASN.2006091062. PMID 17494887. http://jasn.asnjournals.org/content/18/6/1789.full.pdf.
- "A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein". Circ. Res. 99 (12): 1355–66. 2007. doi:10.1161/01.RES.0000251700.00994.0d. PMID 17082479.
- "Increased expression of cyclooxygenase-2 in the renal cortex of human prorenin receptor gene-transgenic rats". Kidney Int. 70 (4): 641–6. 2006. doi:10.1038/sj.ki.5001627. PMID 16807542.
- "Elevated blood pressure and heart rate in human renin receptor transgenic rats". Hypertension 47 (3): 552–6. 2006. doi:10.1161/01.HYP.0000199912.47657.04. PMID 16401765.
- "Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms". Kidney Int. 69 (1): 105–13. 2006. doi:10.1038/sj.ki.5000011. PMID 16374430.
- "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. 2007. doi:10.1093/dnares/12.2.117. PMID 16303743.
- "A unique exonic splice enhancer mutation in a family with X-linked mental retardation and epilepsy points to a novel role of the renin receptor". Hum. Mol. Genet. 14 (8): 1019–27. 2005. doi:10.1093/hmg/ddi094. PMID 15746149.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Novel mental retardation-epilepsy syndrome linked to Xp21.1-p11.4". Ann. Neurol. 51 (1): 45–50. 2002. doi:10.1002/ana.10051. PMID 11782983.
- "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. 2000. doi:10.1073/pnas.160270997. PMID 10931946. Bibcode: 2000PNAS...97.9543H.
External links
- ATP6AP2 human gene location in the UCSC Genome Browser.
- ATP6AP2 human gene details in the UCSC Genome Browser.
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