Biology:Rohon–Beard cell

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Short description: Cells are specialized neurons with mechanoreceptive properties.

Zebrafish embryo 48 hours after fertilization. The arrows indicate four Rohon–Beard neurons.[1]

Rohon–Beard cells are specialized primary neurons with mechanoreceptive properties.[2][3] They occur during the embryonic stage of development and are found in the dorsal part of the spinal cord in fishes and amphibians.[4][5][6] John Beard and Joseph Victor Rohon first described these cells, independently of each other.[7][8] Sigmund Freud also described them as part of his Medical studies on Lampreys (Petromyzon planeri)[9]

Rohon–Beard neurons develop on the border between the ectoderm epidermal (surface) and neuroectoderm, first in the order of receptor neurons.[10][11]

The old paradigm described Rohon–Beard cells as transient during the course of ontogenetic development (e.g. in zebrafish during the first two to four weeks of development, at the late larval, early juvenile stage to be, replaced by a dorsal root ganglion of spinal nerves)[12][13][14][15] and being eliminated by apoptosis.[16][17][18][19][20] However, recent work re-examined the question and determined that the entire complement of Rohon-Beard neurons does not disappear in zebrafish, and persist until at least juvenile stages.[21][22] Furthermore, Rohon-Beard neurons did not show any signs of canonical programmed cell death.

See also

References

  1. ↑ "Changes in gravitational force affect gene expression in developing organ systems at different developmental times". BMC Developmental Biology 5: 10. May 2005. doi:10.1186/1471-213X-5-10. PMID 15927051. 
  2. ↑ "Sensory physiology, anatomy and immunohistochemistry of Rohon-Beard neurones in embryos of Xenopus laevis". The Journal of Physiology 348 (1): 511–525. March 1984. doi:10.1113/jphysiol.1984.sp015122. PMID 6201612. 
  3. ↑ "Primary Motoneurons of the Zebrafish" (in en). Systems Approaches to Developmental Neurobiology. Boston, MA: Springer US. 1990. pp. 41–47. doi:10.1007/978-1-4684-7281-3_5. ISBN 978-1-4684-7281-3. https://link.springer.com/chapter/10.1007/978-1-4684-7281-3_5. Retrieved 2025-02-03. 
  4. ↑ Amphibian morphogenesi. Clifton, N.J.: Humana. 1984. ISBN 0-89603-043-1. 
  5. ↑ "Correlated anatomical and physiological studies of the growth of the nervous system of amphibia" (in en). Journal of Comparative Neurology 24 (2): 161–232. April 1914. doi:10.1002/cne.900240205. ISSN 0021-9967. https://onlinelibrary.wiley.com/doi/10.1002/cne.900240205. 
  6. ↑ "Rohon-Beard Neuron in Zebrafish" (in en). Zebrafish, Medaka, and Other Small Fishes. Singapore: Springer Singapore. 2018. pp. 59–81. doi:10.1007/978-981-13-1879-5_4. ISBN 978-981-13-1878-8. http://link.springer.com/10.1007/978-981-13-1879-5_4. Retrieved 2025-02-03. 
  7. ↑ "IV. On the early development of Lepidosteus osseus . — Preliminary notice" (in en). Proceedings of the Royal Society of London 46 (280-285): 108–118. 1890-12-31. doi:10.1098/rspl.1889.0015. ISSN 0370-1662. https://royalsocietypublishing.org/doi/10.1098/rspl.1889.0015. 
  8. ↑ (in de) Zur Histiogenese des Rückenmarkes der Forelle: Aus dem histiologischen Laboratorium zu München.. Verlag der Bayerischen Akademie der Wissenschaften (Publishing House of the Bavarian Academy of Sciences). 1884. 
  9. ↑ (in de) Über den Ursprung der hinteren Nervenwurzeln im Rückenmark von Ammocoetes (Petromyzon planeri).. 1877. 
  10. ↑ "Transcriptional control of Rohon-Beard sensory neuron development at the neural plate border". Developmental Dynamics 238 (4): 931–943. April 2009. doi:10.1002/dvdy.21915. PMID 19301392. 
  11. ↑ "Zebrafish narrowminded suggests a genetic link between formation of neural crest and primary sensory neurons". Development 126 (18): 3969–3979. September 1999. doi:10.1242/dev.126.18.3969. PMID 10457007. 
  12. ↑ "Zebrafish Rohon-Beard neuron development: cdk5 in the midst". Neurochemical Research 34 (6): 1129–1137. June 2009. doi:10.1007/s11064-008-9885-4. PMID 19067160. 
  13. ↑ "Identification of spinal neurons in the embryonic and larval zebrafish". The Journal of Comparative Neurology 302 (3): 603–616. December 1990. doi:10.1002/cne.903020315. PMID 1702120. 
  14. ↑ "Screen for mutations affecting development of Zebrafish neural crest". Developmental Genetics 18 (1): 11–17. 1996. doi:10.1002/(SICI)1520-6408(1996)18:1<11::AID-DVG2>3.0.CO;2-4. PMID 8742830. 
  15. ↑ "Primary neurons that express the L2/HNK-1 carbohydrate during early development in the zebrafish". Development 110 (2): 491–504. October 1990. doi:10.1242/dev.110.2.491. PMID 1723944. 
  16. ↑ "Slow degeneration of zebrafish Rohon-Beard neurons during programmed cell death". Developmental Dynamics 229 (1): 30–41. January 2004. doi:10.1002/dvdy.10488. PMID 14699575. 
  17. ↑ "Disappearance of Rohon-Beard neurons from the spinal cord of larval Xenopus laevis". The Journal of Comparative Neurology 264 (1): 47–55. October 1987. doi:10.1002/cne.902640105. PMID 3680623. 
  18. ↑ "Activity regulates programmed cell death of zebrafish Rohon-Beard neurons". Development 128 (18): 3511–3520. September 2001. doi:10.1242/dev.128.18.3511. PMID 11566856. 
  19. ↑ "Programmed cell death in zebrafish rohon beard neurons is influenced by TrkC1/NT-3 signaling". Developmental Biology 226 (2): 220–230. October 2000. doi:10.1006/dbio.2000.9860. PMID 11023682. 
  20. ↑ "Long-lived zebrafish Rohon-Beard cells". Developmental Biology 464 (1): 45–52. August 2020. doi:10.1016/j.ydbio.2020.05.003. PMID 32473165. 
  21. ↑ "Complete persistence of the primary somatosensory system in zebrafish". Developmental Biology 515: 178–185. November 2024. doi:10.1016/j.ydbio.2024.05.004. PMID 39021074. 
  22. ↑ "Rohon-beard neurons do not succumb to programmed cell death during zebrafish development". Developmental Biology 515: 186–198. November 2024. doi:10.1016/j.ydbio.2024.06.020. PMID 38944329. 



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