Biology:SCO-spondin
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
SCO-spondin is a protein that in humans is encoded by the SSPO gene.[1][2][3] SCO-spondin is secreted by the subcommissural organ, and contributes to commissural axon growth and the formation of Reissner's fiber, a fibrous aggregation of secreted molecules extending from the subcommissural organ to the end of the spinal cord.[4]
References
- ↑ "SCO-spondin: a new member of the thrombospondin family secreted by the subcommissural organ is a candidate in the modulation of neuronal aggregation". Journal of Cell Science. 109 109 ( Pt 5) (5): 1053–61. May 1996. doi:10.1242/jcs.109.5.1053. PMID 8743952.
- ↑ "Subcommissural organ/Reissner's fiber complex: characterization of SCO-spondin, a glycoprotein with potent activity on neurite outgrowth". Glia 32 (2): 177–91. November 2000. doi:10.1002/1098-1136(200011)32:2<177::AID-GLIA70>3.0.CO;2-V. PMID 11008217.
- ↑ "Entrez Gene: SSPO SCO-spondin homolog (Bos taurus)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23145.
- ↑ "SCO-spondin is evolutionarily conserved in the central nervous system of the chordate phylum". Neuroscience 88 (2): 655–64. January 1999. doi:10.1016/s0306-4522(98)00252-8. PMID 10197783.
Further reading
- "The thrombospondin type 1 repeat (TSR) and neuronal differentiation: roles of SCO-spondin oligopeptides on neuronal cell types and cell lines". International Review of Cytology 230: 1–39. 2004. doi:10.1016/S0074-7696(03)30001-4. PMID 14692680.
- "The complex multidomain organization of SCO-spondin protein is highly conserved in mammals". Brain Research Reviews 53 (2): 321–7. February 2007. doi:10.1016/j.brainresrev.2006.09.007. PMID 17126404.
- "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research 5 (1): 31–9. February 1998. doi:10.1093/dnares/5.1.31. PMID 9628581.
- "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research 12 (11): 1773–84. November 2002. doi:10.1101/gr.406902. PMID 12421765.
- "Mouse SCO-spondin, a gene of the thrombospondin type 1 repeat (TSR) superfamily expressed in the brain". Gene 312: 263–70. July 2003. doi:10.1016/S0378-1119(03)00622-X. PMID 12909363.
- "Placental expression of SCO-spondin during mouse and human development". Gene Expression Patterns 4 (3): 309–14. May 2004. doi:10.1016/j.modgep.2003.10.004. PMID 15053980.
- "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science 308 (5725): 1149–54. May 2005. doi:10.1126/science.1108625. PMID 15790807. Bibcode: 2005Sci...308.1149C.
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