Biology:SEC61B
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Short description: Mammalian protein found in Homo sapiens
 Generic protein structure example |
Protein transport protein Sec61 subunit beta is a protein that in humans is encoded by the SEC61B gene.[1][2][3]
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The Sec61 complex forms a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.[3]
References
- ↑ "Evolutionary conservation of components of the protein translocation complex". Nature 367 (6464): 654–7. Mar 1994. doi:10.1038/367654a0. PMID 8107851. Bibcode: 1994Natur.367..654H.
- ↑ "The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment". J Cell Sci 112 (10): 1477–86. Aug 1999. doi:10.1242/jcs.112.10.1477. PMID 10212142.
- ↑ 3.0 3.1 "Entrez Gene: SEC61B Sec61 beta subunit". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=10952.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction". Nature 384 (6608): 432–8. 1997. doi:10.1038/384432a0. PMID 8945469.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation complex". Biochem. J. 331 (Pt 1): 161–7. 1998. doi:10.1042/bj3310161. PMID 9512475.
- "Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex". J. Biol. Chem. 273 (19): 11887–94. 1998. doi:10.1074/jbc.273.19.11887. PMID 9565615.
- "The β Subunit of the Sec61 Complex Facilitates Cotranslational Protein Transport and Interacts with the Signal Peptidase during Translocation". J. Cell Biol. 141 (4): 887–94. 1998. doi:10.1083/jcb.141.4.887. PMID 9585408.
- "The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary". J. Biol. Chem. 273 (45): 29873–8. 1998. doi:10.1074/jbc.273.45.29873. PMID 9792704.
- "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit". FEBS Lett. 459 (1): 69–74. 1999. doi:10.1016/S0014-5793(99)01188-6. PMID 10508919.
- "Stress-Associated Endoplasmic Reticulum Protein 1 (Serp1)/Ribosome-Associated Membrane Protein 4 (Ramp4) Stabilizes Membrane Proteins during Stress and Facilitates Subsequent Glycosylation". J. Cell Biol. 147 (6): 1195–204. 2000. doi:10.1083/jcb.147.6.1195. PMID 10601334.
- "Mammalian Sec61 is associated with Sec62 and Sec63". J. Biol. Chem. 275 (19): 14550–7. 2000. doi:10.1074/jbc.275.19.14550. PMID 10799540.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. 2004. doi:10.1038/nature02465. PMID 15164053. Bibcode: 2004Natur.429..369H.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1". Nature 436 (7048): 290–3. 2005. doi:10.1038/nature03670. PMID 16015337. Bibcode: 2005Natur.436..290B.
- "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. 2005. doi:10.1021/pr050048h. PMID 16083285.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- "Role of the Sec61 Translocon in EGF Receptor Trafficking to the Nucleus and Gene Expression". Mol. Biol. Cell 18 (3): 1064–72. 2007. doi:10.1091/mbc.E06-09-0802. PMID 17215517.
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